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Selenium in thyroid disorders — essential knowledge for clinicians

Winther, Kristian Hillert, Rayman, Margaret, Bonnema, Steen Joop and Hegedus, Lazlo (2020) Selenium in thyroid disorders — essential knowledge for clinicians Nature Reviews Endocrinology, 16. pp. 165-176.

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Abstract

In the 1990s, selenium was identified as a component of an enzyme that activates thyroid hormone; since this discovery, the relevance of selenium to thyroid health has been widely studied. Selenium, known primarily for the antioxidant properties of selenoenzymes, is obtained mainly from meat, seafood and grains. Intake levels vary across the world owing largely to differences in soil content and factors affecting its bioavailability to plants. Adverse health effects have been observed at both extremes of intake, with a narrow optimum range. Epidemiological studies have linked an increased risk of autoimmune thyroiditis, Graves disease and goitre to low selenium status. Trials of selenium supplementation in patients with chronic autoimmune thyroiditis have generally resulted in reduced thyroid autoantibody titre without apparent improvements in the clinical course of the disease. In Graves disease, selenium supplementation might lead to faster remission of hyperthyroidism and improved quality of life and eye involvement in patients with mild thyroid eye disease. Despite recommendations only extending to patients with Graves ophthalmopathy, selenium supplementation is widely used by clinicians for other thyroid phenotypes. Ongoing and future trials might help identify individuals who can benefit from selenium supplementation, based, for instance, on individual selenium status or genetic profile.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Winther, Kristian Hillert
Rayman, MargaretM.Rayman@surrey.ac.uk
Bonnema, Steen Joop
Hegedus, Lazlo
Date : 30 January 2020
DOI : 10.1038/s41574-019-0311-6
Copyright Disclaimer : Copyright © 2020, Springer Nature
Depositing User : James Marshall
Date Deposited : 13 Mar 2020 14:45
Last Modified : 13 Mar 2020 14:45
URI: http://epubs.surrey.ac.uk/id/eprint/853926

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