University of Surrey

Test tubes in the lab Research in the ATI Dance Research

RTVue XR AngioVue Optical Coherence Tomography Angiography Software Upgrade Impacts on Retinal Thickness and Vessel Density Measurements

Sampson, Danuta, Ali, Noah, Au Young, Alex, Jeewa, Rumaanah, Rajgopal, Saumya, Dutt, Deepaysh D.C.S, Mohamed, Sharaf, Mohamed, Shehata, Hansen, Alex, Menghini, Moreno and Chen, Fred K. (2020) RTVue XR AngioVue Optical Coherence Tomography Angiography Software Upgrade Impacts on Retinal Thickness and Vessel Density Measurements Translational Vision Science & Technology, 9 (10).

i2164-2591-215-1-1715.pdf - Version of Record
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (4MB) | Preview


Purpose: To determine the impact of an AngioVue software upgrade on total retinal thickness (RT) and inner retinal vessel density (VD) measurements derived from optical coherence tomography angiography (OCTA). Methods:OptovueOCTA images (3×3mm) from126 individuals (105healthy eyes and 72 eyes with retinal disease)were acquired before an upgrade of the AngioVue software, which resulted in an inward shift of the outer boundary of the inner retinal vessels and improved Bruch’s membrane segmentation. Total RT and inner retinal VD values were extracted before and after the software upgrade for comparison. Bias and limits of agreement (LA) were calculated. Results: The mean (SD) age of participants was 46 (17) years. Mean (LA) foveal RT increased by 3.0 (–11 to +17) and 3.7 (–11 to +18) μm (P < 0.001) and parafoveal RT increased by 9.7 (–3.8 to +23) and 6.4 (–2.5 to +15) μm (P < 0.001) in healthy and diseased retina, respectively.Mean (LA) foveal inner retinal VD decreased by 6.6 (2.5–11) and 7.7 (0.4–15) percentage units (P < 0.001) and parafoveal inner retinal VD decreased by 4.1 (1.2–7.0) and 4.7 (0.5–8.9) percentage units (P < 0.001) in healthy and diseased retina, respectively. Conclusions: The AngioVue software upgrade resulted in an unexpected increase in total RT and an expected reduction in inner retinal VD measurements in all regions due to altered segmentation. Translational Relevance: RT and VD measures derived from the newer AngioVue software version are not directly comparable to the reported normative data derived from the older software.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering
Authors :
Ali, Noah
Au Young, Alex
Jeewa, Rumaanah
Rajgopal, Saumya
Dutt, Deepaysh D.C.S
Mohamed, Sharaf
Mohamed, Shehata
Hansen, Alex
Menghini, Moreno
Chen, Fred K.
Date : 12 February 2020
OA Location :
Copyright Disclaimer : Copyright 2020 The Authors
Uncontrolled Keywords : OCTA; optical coherence tomography angiography; Optovue, AngioVue; retinal capillary density; split-spectrum amplitude decorrelation angiography; normative data
Depositing User : James Marshall
Date Deposited : 18 Feb 2020 16:55
Last Modified : 18 Feb 2020 16:55

Actions (login required)

View Item View Item


Downloads per month over past year

Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800