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A Topological Cluster of Differentially Regulated Genes in Mice Lacking PER3

Van Der Veen, Daan, Laing, Emma, Bae, Sung-Eun, Johnston, Jonathan, Dijk, Derk-Jan and Archer, Simon (2020) A Topological Cluster of Differentially Regulated Genes in Mice Lacking PER3 Frontiers in Molecular Neuroscience, 13 (15).

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Abstract

Polymorphisms in the human circadian clock gene PERIOD3 (PER3) are associated with a wide variety of phenotypes such as diurnal preference, delayed sleep phase disorder, sleep homeostasis, cognitive performance, bipolar disorder, type 2 diabetes, cardiac regulation, cancer, light sensitivity, hormone and cytokine secretion, and addiction. However, the molecular mechanisms underlying these phenotypic associations remain unknown. Per3 knockout mice (Per3

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Van Der Veen, DaanD.Vanderveen@surrey.ac.uk
Laing, Emma
Bae, Sung-Eun
Johnston, JonathanJ.Johnston@surrey.ac.uk
Dijk, Derk-JanD.J.Dijk@surrey.ac.uk
Archer, SimonSimon.Archer@surrey.ac.uk
Date : 13 February 2020
Funders : Biotechnology and Biological Sciences Research Council (BBSRC)
OA Location : https://www.frontiersin.org/articles/10.3389/fnmol.2020.00015/full?utm_source=F-NTF&utm_medium=EMLX&utm_campaign=PRD_FEOPS_20170000_ARTICLE
Copyright Disclaimer : Copyright © 2020 Van der Veen, Laing, Bae, Johnston, Dijk and Archer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Uncontrolled Keywords : mouse, circadian, topological associating domain, metabolism, transcriptome
Depositing User : James Marshall
Date Deposited : 13 Feb 2020 16:53
Last Modified : 13 Feb 2020 16:53
URI: http://epubs.surrey.ac.uk/id/eprint/853744

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