University of Surrey

Test tubes in the lab Research in the ATI Dance Research

The Profiles and Correlates of Psychopathology in Adolescents and Adults with Williams, Fragile X and Prader-Willi Syndromes

Royston, R., Oliver, C., Howlin, P., Dosse, A., Armitage, P., Moss, J. and Waite, J. (2019) The Profiles and Correlates of Psychopathology in Adolescents and Adults with Williams, Fragile X and Prader-Willi Syndromes Journal of Autism and Developmental Disorders.

Full text not available from this repository.

Abstract

Psychopathology is prevalent in Williams (WS), fragile X (FXS) and Prader-Willi (PWS) syndromes. However, little is known about the potential correlates of psychopathology in these groups. A questionnaire study was completed by 111 caregivers of individuals with WS (n = 35); FXS (n = 50) and PWS (n = 26). Mean age was 26 years (range 12-57 years); 74 (67%) were male. Multiple regression analyses indicated that higher rates of health problems and sensory impairments predicted higher psychopathology in WS (p <.0001). In PWS, poorer adaptive ability predicted higher overall psychiatric disturbance (p =.001), generalised anxiety (p =.006) and hyperactivity (p =.003). There were no significant predictors in FXS. This study highlights dissociations in the potential risk markers of psychopathology between genetic syndromes. Implications for intervention are discussed.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Psychology
Authors :
NameEmailORCID
Royston, R.
Oliver, C.
Howlin, P.
Dosse, A.
Armitage, P.
Moss, J.j.moss@surrey.ac.uk
Waite, J.
Date : 4 December 2019
DOI : 10.1007/s10803-019-04317-1
Copyright Disclaimer : © 2019, The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Uncontrolled Keywords : Williams syndrome; Prader–Willi syndrome; Fragile X syndrome; Psychopathology; Correlates
Additional Information : This study was funded by Cerebra and the Williams Syndrome Foundation.
Depositing User : Diane Maxfield
Date Deposited : 03 Feb 2020 16:17
Last Modified : 03 Feb 2020 16:17
URI: http://epubs.surrey.ac.uk/id/eprint/853568

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800