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Vectorial birefringence imaging by optical coherence microscopy for assessing fibrillar microstructures in the cornea and limbus

Li, Qingyun, Karnowski, Karol, Untracht, Gabrielle, Noble, Peter B., Cense, Barry, Villiger, Martin and Sampson, David (2020) Vectorial birefringence imaging by optical coherence microscopy for assessing fibrillar microstructures in the cornea and limbus Biomedical Optics Express.

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Abstract

The organization of fibrillar tissue on the micrometer scale carries direct implications for health and disease but remains difficult to assess in vivo. Polarization-sensitive optical coherence tomography measures birefringence, which relates to the microscopic arrangement of fibrillar tissue components. Here, we demonstrate a critical improvement in leveraging this contrast mechanism by employing the improved spatial resolution of focus-extended optical coherence microscopy (1.4 μm axially in air and 1.6 μm laterally, over more than 70 μm depth of field). Vectorial birefringence imaging of sheep cornea ex vivo reveals its lamellar organization into thin sections

Item Type: Article
Divisions : Surrey research (other units)
Authors :
NameEmailORCID
Li, Qingyun
Karnowski, Karol
Untracht, Gabrielle
Noble, Peter B.
Cense, Barry
Villiger, Martin
Sampson, Davidd.sampson@surrey.ac.uk
Date : 24 January 2020
DOI : https://doi.org/10.1364/BOE.382755
Copyright Disclaimer : © 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
Depositing User : James Marshall
Date Deposited : 03 Feb 2020 10:53
Last Modified : 03 Feb 2020 10:53
URI: http://epubs.surrey.ac.uk/id/eprint/853549

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