University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Impaired platelet dependent thrombin generation associated with thrombocytopenia is improved by prothrombin complex concentrates in vitro

Chowdhary, Pratima, Lancaster, Simon, Hamid, Colleen, Slatter, David, Morris, Richard, Foley, Jonathan H., Gomez, Keith, Brodkin, Edgar, Fox, Thomas, Gatt, Alex and McVey, John (2019) Impaired platelet dependent thrombin generation associated with thrombocytopenia is improved by prothrombin complex concentrates in vitro Research and Practice in Thrombosis and Haemostasis.

[img] Text
RPTH-2019-00100.R2_Proof_6 December 2019.pdf - Accepted version Manuscript
Restricted to Repository staff only until 14 December 2020.

Download (1MB)

Abstract

Impaired thrombin generation (TG) is seen in patients with acquired coagulopathy, due to a combination of low coagulation factors and decreased platelet count (thrombocytopenia). Low coagulation factors seen in acquired coagulopathy are typically treated with plasma and occasionally with prothrombin complex concentrates (PCCs), and the decreased platelet count can be treated with platelet transfusions. Our study investigated the influence of PCCs on impaired generation of thrombin in the above context. Generation of adequate thrombin is crucial for the formation of a stable blood clot. We conclude that further clinical studies would be of interest to investigate the role of PCCs in the management of complex coagulopathy characterized by abnormal coagulation and mild-to-moderate thrombocytopenia.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors : Chowdhary, Pratima, Lancaster, Simon, Hamid, Colleen, Slatter, David, Morris, Richard, Foley, Jonathan H., Gomez, Keith, Brodkin, Edgar, Fox, Thomas, Gatt, Alex and McVey, John
Date : 13 December 2019
Uncontrolled Keywords : blood coagulation disorders, blood platelets, prothrombin complex concentrates, thrombin, thrombocytopenia, acquired coagulopathy
Depositing User : James Marshall
Date Deposited : 28 Jan 2020 13:39
Last Modified : 28 Jan 2020 13:39
URI: http://epubs.surrey.ac.uk/id/eprint/853451

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800