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Impaired platelet dependent thrombin generation associated with thrombocytopenia is improved by prothrombin complex concentrates in vitro

Chowdhary, Pratima, Lancaster, Simon, Hamid, Colleen, Slatter, David, Morris, Richard, Foley, Jonathan H., Gomez, Keith, Brodkin, Edgar, Fox, Thomas, Gatt, Alex and McVey, John (2020) Impaired platelet dependent thrombin generation associated with thrombocytopenia is improved by prothrombin complex concentrates in vitro Research and Practice in Thrombosis and Haemostasis, 4 (2). pp. 334-342.

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Abstract

Impaired thrombin generation (TG) is seen in patients with acquired coagulopathy, due to a combination of low coagulation factors and decreased platelet count (thrombocytopenia). Low coagulation factors seen in acquired coagulopathy are typically treated with plasma and occasionally with prothrombin complex concentrates (PCCs), and the decreased platelet count can be treated with platelet transfusions. Our study investigated the influence of PCCs on impaired generation of thrombin in the above context. Generation of adequate thrombin is crucial for the formation of a stable blood clot. We conclude that further clinical studies would be of interest to investigate the role of PCCs in the management of complex coagulopathy characterized by abnormal coagulation and mild-to-moderate thrombocytopenia.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Chowdhary, Pratima
Lancaster, Simon
Hamid, Colleen
Slatter, David
Morris, Richard
Foley, Jonathan H.
Gomez, Keith
Brodkin, Edgar
Fox, Thomas
Gatt, Alex
McVey, Johnj.mcvey@surrey.ac.uk
Date : 14 February 2020
Funders : Royal Free Charity
DOI : 10.1002/rth2.12310
Copyright Disclaimer : © 2020 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals, Inc on behalf of International Society on Thrombosis and Haemostasis. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Uncontrolled Keywords : Blood coagulation disorders; Blood platelets; Prothrombin complex concentrates; Thrombin; Thrombocytopenia; Acquired coagulopathy
Depositing User : James Marshall
Date Deposited : 28 Jan 2020 13:39
Last Modified : 23 Apr 2020 12:46
URI: http://epubs.surrey.ac.uk/id/eprint/853451

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