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Biological activity of manganese(i) tricarbonyl complexes on multidrug-resistant Gram-negative bacteria: From functional studies to in vivo activity in Galleria mellonella

Güntzel, Paul, Nagel, Christoph, Weigelt, Jeanette, Betts, Jono W., Pattrick, Calum A., Southam, Hannah M., La Ragione, Roberto M., Poole, Robert K. and Schatzschneider, Ulrich (2019) Biological activity of manganese(i) tricarbonyl complexes on multidrug-resistant Gram-negative bacteria: From functional studies to in vivo activity in Galleria mellonella Metallomics.

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Abstract

Three new manganese(I) tricarbonyl complexes [Mn(bpqa-κ³N)(CO)₃]Br, [Mn(bqpa-κ³N)(CO)₃]Br, and [Mn(CO)₃(tqa-κ³N)]Br as well as the previously described compound [Mn(CO)₃(tpa-κ³N)]Br with bpqa = bis(2-pyridinylmethyl)(2-quinolinylmethyl)amine, bqpa = bis(2-quinolinylmethyl)(2-pyridinylmethyl)amine, tqa = tris(2-quinolinylmethyl)amine, and tpa = tris(2-pyridinylmethyl)amine were examined for their antibacterial activities on 14 different multidrug-resistant clinical isolates of Acinetobacter baumannii and Pseudomonas aeruginosa, in recognition of the current antimicrobial resistance (AMR) concerns with these pathogens. Minimal inhibitory concentrations (MIC) of the most potent tqa compound were in the mid-micromolar range and generally lower than that of the free ligand. Activity against both bacterial species increased with the number of quinolinylmethyl groups and lipophilicity in the order of tpa < bpqa < bqpa ≈ tqa, consistent with measured increases in release of ATP, a uniquely cytoplasmic biomolecule and induced permeability to exogenous fluorescent intercalating compounds. [Mn(CO)₃(tqa-κ³N)]Br was also evaluated in the Galleria mellonella model of infection, and displayed a lack of host toxicity combined with effective bacterial clearance.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Güntzel, Paul
Nagel, Christoph
Weigelt, Jeanette
Betts, Jono W.jono.betts@surrey.ac.uk
Pattrick, Calum A.
Southam, Hannah M.
La Ragione, Roberto M.R.Laragione@surrey.ac.uk
Poole, Robert K.
Schatzschneider, Ulrich
Date : 19 September 2019
Funders : Deutsche Forschungsgemeinschaft (DFG), Biotechnology and Biological Sciences Research Council (BBSRC)
DOI : 10.1039/C9MT00224C
Copyright Disclaimer : © The Royal Society of Chemistry 2019
Depositing User : Clive Harris
Date Deposited : 25 Nov 2019 15:31
Last Modified : 27 Nov 2019 08:41
URI: http://epubs.surrey.ac.uk/id/eprint/853200

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