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Textile-based non-invasive lithium drug monitoring: a proof-of-concept study for wearable sensing

Sweilam, Mona N., Cordery, Sarah F., Totti, Stella, Velliou, Eirini G., Campagnolo, Paola, Varcoe, John R., Delgado-Charro, M. Begoña and Crean, Carol (2020) Textile-based non-invasive lithium drug monitoring: a proof-of-concept study for wearable sensing Biosensors and Bioelectronics, 150, 111897.

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Abstract

Flexible wearable chemical sensors are emerging tools which target diagnosis and monitoring of medical conditions. One of the potential applications of wearable chemical sensors is therapeutic drug monitoring for drugs that have a narrow therapeutic range such as lithium. We have investigated the possibility of developing a fibre-based device for non-invasive lithium drug monitoring in interstitial fluid. A flexible cotton-based lithium sensor was coupled with a carbon fibre-based reference electrode to obtain a potentiometric device. In vitro reverse iontophoresis experiments were performed to extract Li+ from under porcine skin by applying a current density of 0.4 mA cm-2 via two electrodes. Carbon fibre-based reverse iontophoresis electrodes were fabricated and used instead of a conventional silver wire-based version and comparable results were obtained. The fibre-based Li+ sensor and reference electrodes were capable of determining the Li+ concentration in samples collected via reverse iontophoresis and the results compared well to those obtained by ion chromatography. Additionally, biocompatibility of the used materials have been tested. Promising results were obtained which confirm the possibility of monitoring lithium in interstitial fluid using a wearable sensor.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
NameEmailORCID
Sweilam, Mona N.m.sweilam@surrey.ac.uk
Cordery, Sarah F.
Totti, Stellastyliani.totti@surrey.ac.uk
Velliou, Eirini G.e.velliou@surrey.ac.uk
Campagnolo, Paolap.campagnolo@surrey.ac.uk
Varcoe, John R.J.Varcoe@surrey.ac.uk
Delgado-Charro, M. Begoña
Crean, Carolc.crean@surrey.ac.uk
Date : 15 February 2020
DOI : 10.1016/j.bios.2019.111897
Copyright Disclaimer : © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Ion-selective electrodes,; Non-invasive wearable sensors,; Reverse iontophoresis; Lithium drug monitoring; Interstitial fluid; Biocompatibility.
Additional Information : The authors would like to thank the Newton-Mosharafa PhD programme (British council in Egypt and Mission sectors & cultural affairs in Egypt) for providing funding for this work. Furthermore, the author thanks the RSC researcher mobility grant which facilitate the carrying out of reverse iontophoresis experiments in the University of Bath.
Depositing User : Diane Maxfield
Date Deposited : 19 Nov 2019 13:16
Last Modified : 28 Apr 2020 15:48
URI: http://epubs.surrey.ac.uk/id/eprint/853178

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