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Antibacterial Copper-Doped Calcium Phosphate Glasses for Bone Tissue Regeneration

Foroutan, Farzad, McGuire, Jamie, Gupta, Priyanka, Nikolaou, Athanasios, Kyffin, Benjamin, Kelly, Nicole L., Hanna, John V., Gutierrez-Merino, Jorge, Knowles, Jonathan C., Baek, Song-Yi , Velliou, Eirini and Carta, Daniela (2019) Antibacterial Copper-Doped Calcium Phosphate Glasses for Bone Tissue Regeneration ACS Biomaterials Science & Engineering.

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Abstract

Calcium phosphate glasses are a promising new generation of biomaterials that can simultaneously induce tissue regeneration and controlled release of therapeutic molecules. In this work, novel calcium phosphate glasses containing 0, 2, 4, and 6 mol % Cu2+ were synthesized via room temperature precipitation reaction in aqueous solution. The effect of Cu2+ addition on the glass properties and structure was investigated using thermal analysis, 31P solidstate MAS NMR, Raman spectroscopy, and X-ray diffraction. All glasses crystallize at temperature >500 °C and are mainly formed by Q1 groups. The release of P, Ca, and Cu in solution over time was monitored via inductively coupled plasma-optical emission spectroscopy. It was found that with increasing Cu content, the amount of P and Ca released decreases whereas the amount of Cu released increases. The effect of Cu2+ release on the antibacterial activity against S. aureus, a bacterial strain commonly found in postsurgery infections, has been investigated. The addition of copper has been shown to infer the glasses antibacterial properties. As expected, the antibacterial activity of the glasses increases with increasing Cu2+ content. Cytocompatibility was assessed by seeding human osteoblast-like osteosarcoma cells Saos-2 (HTB85) on the glass particles. A significant increase in cell number was observed in all the glasses investigated. The copper-doped calcium phosphate glasses have proven to be multifunctional, as they combine bone regenerative properties with antibacterial activity. Therefore, they have great potential as antibacterial bioresorbable materials for hard tissue regeneration.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
NameEmailORCID
Foroutan, Farzadf.foroutan@surrey.ac.uk
McGuire, Jamie
Gupta, Priyankapriyanka.gupta@surrey.ac.uk
Nikolaou, Athanasiosa.nikolaou@surrey.ac.uk
Kyffin, Benjaminb.kyffin@surrey.ac.uk
Kelly, Nicole L.
Hanna, John V.
Gutierrez-Merino, Jorge
Knowles, Jonathan C.
Baek, Song-Yi
Velliou, Eirinie.velliou@surrey.ac.uk
Carta, Danielad.carta@surrey.ac.uk
Date : 11 October 2019
Funders : EPSRC - Engineering and Physical Sciences Research Council, The Royal Society
DOI : 10.1021/acsbiomaterials.9b01291
Copyright Disclaimer : Copyright 2019 American Chemical Society
Uncontrolled Keywords : Calcium phosphate glasses; Bone regeneration; Controlled ion release; Antibacterial activity
Depositing User : Diane Maxfield
Date Deposited : 31 Oct 2019 13:29
Last Modified : 31 Oct 2019 13:29
URI: http://epubs.surrey.ac.uk/id/eprint/853014

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