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Distinguishing between contact and administration of heroin from a single fingerprint using high resolution mass spectrometry

Costa, Catia, Ismail, Mahado, Stevenson, Derek, Gibson, Brian, Webb, Roger and Bailey, Melanie (2019) Distinguishing between contact and administration of heroin from a single fingerprint using high resolution mass spectrometry Journal of Analytical Toxicology.

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Abstract

Fingerprints have been proposed as a promising new matrix for drug testing. In previous work it has been shown that a fingerprint can be used to distinguish between drug users and non-users. Herein, we look at the possibility of using a fingerprint to distinguish between dermal contact and administration of heroin.

Fingerprint samples were collected from (a) 10 patients attending a drug rehabilitation clinic (b) 50 non-drug users (c) participants who touched 2 mg street heroin, before and after various hand cleaning procedures. Oral fluid was also taken from the patients. All samples were analysed using a liquid chromatography – high resolution mass spectrometry (LC-HRMS) method validated in previous work for heroin and 6-AM. The HRMS data was analysed retrospectively for morphine, codeine, 6-acetylcodeine and noscapine. Heroin and 6-AM were detected in all fingerprint samples produced from contact with heroin, even after handwashing. In contrast, morphine, acetylcodeine and noscapine were successfully removed after handwashing.

In patient samples, the detection of morphine, noscapine and acetylcodeine (alongside heroin and 6-AM) gave a closer agreement to patient testimony on whether they had recently used heroin use than the detection of heroin and 6-AM alone.

This research highlights the importance of washing hands prior to donating a fingerprint sample to distinguish recent contact with heroin from heroin use.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
NameEmailORCID
Costa, Catiac.d.costa@surrey.ac.uk
Ismail, Mahadomahado.ismail@surrey.ac.uk
Stevenson, DerekD.Stevenson@surrey.ac.uk
Gibson, Brian
Webb, RogerR.Webb@surrey.ac.uk
Bailey, MelanieM.Bailey@surrey.ac.uk
Date : 2019
Funders : Engineering and Physical Sciences Research Council (EPSRC)
Copyright Disclaimer : © Oxford University Press 2019. All rights reserved. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
Uncontrolled Keywords : Fingerprints; Opiates; Heroin; High resolution mass spectrometry
Related URLs :
Depositing User : Clive Harris
Date Deposited : 30 Oct 2019 08:56
Last Modified : 14 Nov 2019 10:24
URI: http://epubs.surrey.ac.uk/id/eprint/852986

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