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Characterization of internal ribosome entry sites according to secondary structure analysis to classify Border Disease virus strains

Giangaspero, Massimo, Steinbach, Falko, Strong, Rebecca, Decaro, Nicola, Buonavoglia, Canio, Domenis, Lorenzo, Gargano, Pietro, Bailly, Xavier, Apicella, Claudio and Turno, Pasquale (2019) Characterization of internal ribosome entry sites according to secondary structure analysis to classify Border Disease virus strains Journal of Virological Methods, 113704.

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Abstract

Applying palindromic nucleotide substitutions (PNS) method, variable loci of the internal ribosome entry site (IRES) secondary structure in the 5’ untranslated region (UTR) of Border Disease virus sequences were analysed allowing their allocation into ten IRES classes within the species. Sequence characteristics of Turkish and Chinese strains were highly divergent from other genogroups, indicating geographic segregation and micro-evolutive steps within the species. Observed heterogeneity in the BDV species has to be considered for potential implications on diagnostic tests, control and preventive measures.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Giangaspero, Massimo
Steinbach, Falkof.steinbach@surrey.ac.uk
Strong, Rebecca
Decaro, Nicola
Buonavoglia, Canio
Domenis, Lorenzo
Gargano, Pietro
Bailly, Xavier
Apicella, Claudio
Turno, Pasquale
Date : 2019
DOI : 10.1016/j.jviromet.2019.113704
Copyright Disclaimer : © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Border Disease virus; Internal ribosome entry site; Secondary structure
Depositing User : Clive Harris
Date Deposited : 07 Oct 2019 10:29
Last Modified : 07 Oct 2019 10:29
URI: http://epubs.surrey.ac.uk/id/eprint/852884

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