University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Is high-density lipoprotein a modifiable treatment target or just a biomarker for cardiovascular disease?

Whyte, Martin B. (2019) Is high-density lipoprotein a modifiable treatment target or just a biomarker for cardiovascular disease? JRSM Cardiovascular Disease, 8. pp. 1-8.

[img]
Preview
Text
Is high-density lipoprotein a modifiable treatment target or just a biomarker for cardiovascular disease.pdf - Version of Record
Available under License Creative Commons Attribution Non-commercial.

Download (583kB) | Preview

Abstract

Epidemiological data strongly support the inverse association between high-density lipoprotein cholesterol concentration and cardiovascular risk. Over the last three decades, pharmaceutical strategies have been partially successful in raising high-density lipoprotein cholesterol concentration, but clinical outcomes have been disappointing. A recent therapeutic class is the cholesteryl ester transfer protein inhibitor. These drugs can increase circulating high-density lipoprotein cholesterol levels by inhibiting the exchange of cholesteryl ester from high-density lipoprotein for triacylglycerol in larger lipoproteins, such as very low-density lipoprotein and low-density lipoprotein. Recent trials of these agents have not shown clinical benefit. This article will review the evidence for cardiovascular risk associated with high-density lipoprotein cholesterol and discuss the implications of the trial data for cholesteryl ester transfer protein inhibitors.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Whyte, Martin B.m.b.whyte@surrey.ac.uk
Date : 12 August 2019
DOI : 10.1177/2048004019869736
Copyright Disclaimer : © The Author(s) 2019. Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons AttributionNonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us. sagepub.com/en-us/nam/open-access-at-sage).
Depositing User : Clive Harris
Date Deposited : 25 Sep 2019 08:17
Last Modified : 25 Sep 2019 08:17
URI: http://epubs.surrey.ac.uk/id/eprint/852782

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800