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Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study

Hoste, E.A.J., Bagshaw, S.M., Bellomo, R., Cely, C.M., Colman, R., Cruz, D.N., Edipidis, K., Forni, Lui G., Gomersall, C.D., Govil, D. , Honoré, Patrick M., Joannes-Boyau, O., Joannidis, M., Korhonen, A.-M., Lavrentieva, A., Mehta, R.L., Palevsky, P., Roessler, E., Ronco, C., Uchino, S., Vazquez, J.A., Vidal Andrade, E., Webb, S. and Kellum, J.A. (2015) Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study INTENSIVE CARE MEDICINE, 41 (8). pp. 1411-1423.

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Current reports on acute kidney injury (AKI) in the intensive care unit (ICU) show wide variation in occurrence rate and are limited by study biases such as use of incomplete AKI definition, selected cohorts, or retrospective design. Our aim was to prospectively investigate the occurrence and outcomes of AKI in ICU patients.
The Acute Kidney Injury–Epidemiologic Prospective Investigation (AKI-EPI) study was an international cross-sectional study performed in 97 centers on patients during the first week of ICU admission. We measured AKI by Kidney Disease: Improving Global Outcomes (KDIGO) criteria, and outcomes at hospital discharge.
A total of 1032 ICU patients out of 1802 [57.3 %; 95 % confidence interval (CI) 55.0–59.6] had AKI. Increasing AKI severity was associated with hospital mortality when adjusted for other variables; odds ratio of stage 1 = 1.679 (95 % CI 0.890–3.169; p = 0.109), stage 2 = 2.945 (95 % CI 1.382–6.276; p = 0.005), and stage 3 = 6.884 (95 % CI 3.876–12.228; p\0.001). Risk-adjusted rates of AKI and mortality were similar across the world. Patients developing AKI had worse kidney function at hospital discharge with estimated glomerular filtration rate less than 60 mL/min/1.73 m2 in 47.7 % (95 % CI 43.6–51.7) versus 14.8 % (95 % CI 11.9–18.2) in those without AKI, p\0.001.
This is the first multinational cross-sectional study on the epidemiology of AKI in ICU patients using the complete KDIGO criteria. We found that AKI occurred in more than half of ICU patients. Increasing AKI severity was associated with increased mortality, and AKI patients had worse renal function at the time of hospital discharge. Adjusted risks for AKI and mortality were similar across different continents and regions.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Hoste, E.A.J.
Bagshaw, S.M.
Bellomo, R.
Cely, C.M.
Colman, R.
Cruz, D.N.
Edipidis, K.
Forni, Lui
Gomersall, C.D.
Govil, D.
Honoré, Patrick M.
Joannes-Boyau, O.
Joannidis, M.
Korhonen, A.-M.
Lavrentieva, A.
Mehta, R.L.
Palevsky, P.
Roessler, E.
Ronco, C.
Uchino, S.
Vazquez, J.A.
Vidal Andrade, E.
Webb, S.
Kellum, J.A.
Date : 11 July 2015
DOI : 10.1007/s00134-015-3934-7
Copyright Disclaimer : © Springer-Verlag Berlin Heidelberg and ESICM 2015
Uncontrolled Keywords : Acute kidney injury; Critically ill; Renal replacement therapy; Epidemiology; Kidney function; Hospital mortality
Depositing User : Diane Maxfield
Date Deposited : 23 Sep 2019 12:05
Last Modified : 23 Sep 2019 12:05

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