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The pathophysiological basis and consequences of fever

Walter, E.J., Hanna-Jumma, S., Carraretto, M. and Forni, Lui (2016) The pathophysiological basis and consequences of fever Critical Care, 20 (1).

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Abstract

There are numerous causes of a raised core temperature. A fever occurring in sepsis may be associated with a survival benefit. However, this is not the case for non-infective triggers. Where heat generation exceeds heat loss and the core temperature rises above that set by the hypothalamus, a combination of cellular, local, organ-specific, and systemic effects occurs and puts the individual at risk of both short-term and long-term dysfunction which, if severe or sustained, may lead to death. This narrative review is part of a series that will outline the pathophysiology of pyrogenic and non-pyrogenic fever, concentrating primarily on the pathophysiology of non-septic causes.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Walter, E.J.
Hanna-Jumma, S.
Carraretto, M.
Forni, Luil.forni@surrey.ac.uk
Date : 14 July 2016
DOI : 10.1186/s13054-016-1375-5
Copyright Disclaimer : © 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Uncontrolled Keywords : Hyperthermia; Fever; Organ failure; Physiopathology; Heatstroke
Depositing User : Diane Maxfield
Date Deposited : 01 Oct 2019 11:00
Last Modified : 01 Oct 2019 11:00
URI: http://epubs.surrey.ac.uk/id/eprint/852738

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