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Update on sepsis-associated acute kidney injury: Emerging targeted therapies

Doyle, J.F. and Forni, Lui G. (2016) Update on sepsis-associated acute kidney injury: Emerging targeted therapies Biologics: Targets and Therapy, 10. pp. 149-156.

BTT-87385-update-on-sepsis-associated-acute-kidney-injury--sa-aki----e_110716.pdf - Version of Record

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Sepsis-associated acute kidney injury (SA-AKI) is an independent predictor of increased mortality and morbidity. It is essential that further advances in the treatment of sepsis should prioritize targeted therapies in SA-AKI in order to improve these bleak outcomes. As yet, a unique therapy that effectively reduces the impact of acute kidney injury has not been demonstrated. However, the emergence of novel targeted therapies, perhaps in combination, has the possibility of significantly reducing the long-term sequelae of an episode of SA-AKI. In this review, we will focus on the shared etiology of these conditions and how this is managed with targeted therapy and finally the emerging novel therapies that may play an additional role to current treatment strategies.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Doyle, J.F.
Forni, Lui
Date : 7 November 2016
DOI : 10.2147/BTT.S87385
Copyright Disclaimer : 2016 Doyle and Forni. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (
Uncontrolled Keywords : Sepsis; Acute kidney injury; Novel targeted therapy outcome
Depositing User : Diane Maxfield
Date Deposited : 01 Oct 2019 10:42
Last Modified : 01 Oct 2019 10:42

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