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Carbohydrate oxidation and glucose utilisation under hyperglycaemia in aged and young males during exercise at the same relative exercise intensity

Malone, J.J., Bassami, M., Waldron, S.C., Campbell, I.T., Hulton, A.T., Doran, D. and MacLaren, D.P. (2019) Carbohydrate oxidation and glucose utilisation under hyperglycaemia in aged and young males during exercise at the same relative exercise intensity European Journal of Applied Physiology, 119 (1). pp. 235-245.

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Abstract

Purpose: The purpose of the present study was to investigate the age-related carbohydrate oxidation and glucose utilisation rate response during exercise at the same relative intensity under hyperglycaemia in aged and young males. Methods: 16 endurance-trained aged (n = 8; 69.1 ± 5.2 year) and young (n = 8; 22.4 ± 2.9 year) males were studied during 40 min of cycling exercise (60% VO2max)under both hyperglycaemic and euglycaemic (control) conditions. Venous blood samples were collected at baseline, post-infusion, mid- and post-exercise. Carbohydrate and fat oxidation rates were determined at both 15 and 35 min during exercise, and glucose utilisation rates were calculated. Results: The aged group displayed significantly lower rates of carbohydrate oxidation during 42 exercise during maintained hyperglycemia (15 mins = 2.3 ± 0.4 vs. 1.6 ± 0.5 g.min-1; 35 mins 43 = 2.3 ± 0.5 vs. 1.5 ± 0.5 g.min-1) and control (15 mins = 2.2 ± 0.4 vs. 1.6 ± 0.7 g.min-1; 35 mins 44 = 1.9 ± 0.7 vs. 1.3 ± 0.7 g.min-1) conditions (P = 0.01). The rate of glucose utilisation during 45 exercise was also significantly reduced (85.76 ± 23.95 vs 56.67 ± 15.09 uM.kg-1.min-1). There 46 were no differences between age groups for anthropometric measures, fat oxidation, insulin, 47 glucose, NEFA, glycerol and lactate (P > 0.05), although hyperglycemia resulted in elevated 48 glucose and insulin, and attenuated fat metabolite levels. Conclusion: Our findings highlight that ageing results in a reduction in carbohydrate oxidation and utilisation rates during exercise at the same relative exercise intensity.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Malone, J.J.
Bassami, M.
Waldron, S.C.
Campbell, I.T.
Hulton, A.T.a.hulton@surrey.ac.uk
Doran, D.
MacLaren, D.P.
Date : January 2019
DOI : 10.1007/s00421-018-4019-4
Copyright Disclaimer : © Springer-Verlag GmbH Germany, part of Springer Nature 2018
Uncontrolled Keywords : Carbohydrate oxidation; Fat oxidation; Glucose clamp; Insulin; Ageing; Endurance
Depositing User : Diane Maxfield
Date Deposited : 09 Sep 2019 14:44
Last Modified : 09 Sep 2019 14:44
URI: http://epubs.surrey.ac.uk/id/eprint/852575

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