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Homoisoflavonoids Are Potent Glucose Transporter 2 (GLUT2) Inhibitors: A Potential Mechanism for the Glucose-Lowering Properties of Polygonatum odoratum

Wang, Huijun, Fowler, Mark I., Messenger, David J., Terry, Leon A., Gu, Xuelan, Zhou, Luxian, Liu, Ruimin, Su, Juan, Shi, Songshan, Ordaz-Ortiz, Jose Juan , Lian, Guoping, Berry, Mark J. and Wang, Shunchun (2018) Homoisoflavonoids Are Potent Glucose Transporter 2 (GLUT2) Inhibitors: A Potential Mechanism for the Glucose-Lowering Properties of Polygonatum odoratum Journal of Agricultural and Food Chemistry, 66 (12). pp 3137-3145.

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Abstract

Foods of high carbohydrate content such as sucrose or starch increase postprandial blood glucose concentrations. The glucose absorption system in the intestine comprises two components: sodium-dependent glucose transporter-1 (SGLT1) and glucose transporter 2 (GLUT2). Here five sappanin-type (SAP) homoisoflavonoids were identified as novel potent GLUT2 inhibitors, with three of them isolated from the fibrous roots of Polygonatum odoratum (Mill.) Druce. SAP homoisolflavonoids had a stronger inhibitory effect on 25 mM glucose transport (41.6 ± 2.5, 50.5 ± 7.6, 47.5 ± 1.9, 42.6 ± 2.4, and 45.7 ± 4.1% for EA-1, EA-2, EA-3, MOA, and MOB) than flavonoids (19.3 ± 2.2, 11.5 ± 3.7, 16.4 ± 2.4, 5.3 ± 1.0, 3.7 ± 2.2, and 18.1 ± 2.4% for apigenin, luteolin, quercetin, naringenin, hesperetin, and genistein) and phloretin (28.1 ± 1.6%) at 15 μM. SAP homoisoflavonoids and SGLT1 inhibitors were found to synergistically inhibit the uptake of glucose using an in vitro model comprising Caco-2 cells. This observed new mechanism of the glucose-lowering action of P. odoratum suggests that SAP homoisoflavonoids and their combination with flavonoid monoglucosides show promise as naturally functional ingredients for inclusion in foods and drinks designed to control postprandial glucose levels.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
NameEmailORCID
Wang, Huijun
Fowler, Mark I.
Messenger, David J.
Terry, Leon A.
Gu, Xuelan
Zhou, Luxian
Liu, Ruimin
Su, Juan
Shi, Songshan
Ordaz-Ortiz, Jose Juan
Lian, Guopingg.lian@surrey.ac.uk
Berry, Mark J.
Wang, Shunchun
Date : 28 March 2018
Funders : The Unilever Research Colworth Grant, The National Natural Science Foundation of China, The China Postdoctoral Science Foundation funded project
DOI : 10.1021/acs.jafc.8b00107
Copyright Disclaimer : © 2018 American Chemical Society
Uncontrolled Keywords : Polygonatum odoratum; Homoisoflavonoids; GLUT2 inhibitors; Synergy; Glucose control
Additional Information : The authors declare the following competing financial interest(s): H.W. and M.I.F. are named inventors on international patent specification "Edible Composition" initially published in 2017 (WO/2017/036926) that contains partial information found in this manuscript. All other authors declare no competing financial interest.
Depositing User : Diane Maxfield
Date Deposited : 09 Sep 2019 11:28
Last Modified : 09 Sep 2019 11:28
URI: http://epubs.surrey.ac.uk/id/eprint/852566

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