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Tradeoffs between gene expression, growth and phenotypic diversity in microbial populations

Kim, Juhyun, Darlington, Alexander, Salvador, Manuel, Utrilla, José and Jimenez, José I. (2020) Tradeoffs between gene expression, growth and phenotypic diversity in microbial populations Current Opinion in Biotechnology, 62. pp. 29-37.

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Abstract

Bacterial cells have a limited number of resources that can be allocated for gene expression. The intracellular competition for these resources has an impact on the cell physiology. Bacteria have evolved mechanisms to optimize resource allocation in a variety of scenarios, showing a tradeoff between the resources used to maximise growth (e.g. ribosome synthesis) and the rest of cellular functions. Limitations in gene expression also play a role in generating phenotypic diversity, which is advantageous in fluctuating environments, at the expenses of decreasing growth rates. Our current understanding of these tradeoffs can be exploited for biotechnological applications benefiting from the selective manipulation of the allocation of resources.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Kim, Juhyunjuhyun.kim@surrey.ac.uk
Darlington, Alexander
Salvador, Manuelm.salvadordelara@surrey.ac.uk
Utrilla, José
Jimenez, José I.j.jimenez@surrey.ac.uk
Date : April 2020
Funders : Biotechnology and Biological Sciences Research Council (BBSRC), European Union's Horizon 2020, Royal Society, Newton Fund, Leverhulme Trust
DOI : 10.1016/j.copbio.2019.08.004
Copyright Disclaimer : © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Related URLs :
Depositing User : Clive Harris
Date Deposited : 03 Sep 2019 10:46
Last Modified : 21 Oct 2019 11:57
URI: http://epubs.surrey.ac.uk/id/eprint/852527

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