University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Reduced melatonin synthesis in pregnant night workers: Metabolic implications for offspring

Nehme, P.A., Amaral, F., Lowden, A., Skene, D.J., Cipolla-Neto, J. and Moreno, C.R.C. (2019) Reduced melatonin synthesis in pregnant night workers: Metabolic implications for offspring Medical Hypotheses, 132, 109353. pp. 1-5.

[img]
Preview
Text
Reduced melatonin synthesis in pregnant night workers.pdf - Accepted version Manuscript

Download (213kB) | Preview

Abstract

Several novel animal studies have shown that intrauterine metabolic programming can be modified in the event of reduced melatonin synthesis during pregnancy, leading to glucose intolerance and insulin resistance in the offspring. It is therefore postulated that female night workers when pregnant may expose the offspring to unwanted health threats. This may be explained by the fact that melatonin is essential for regulating energy metabolism and can influence reproductive activity. Moreover, the circadian misalignment caused by shift work affects fertility and the fetus, increasing the risk of miscarriage, premature birth and low birth weight, phenomena observed in night workers. Thus, we hypothesize that light-induced melatonin suppression as a result of night work may alter intrauterine metabolic programming in pregnant women, potentially leading to metabolic disorders in their offspring.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Nehme, P.A.
Amaral, F.
Lowden, A.
Skene, D.J.D.Skene@surrey.ac.uk
Cipolla-Neto, J.
Moreno, C.R.C.
Date : November 2019
DOI : 10.1016/j.mehy.2019.109353
Copyright Disclaimer : © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Pregnancy; Offspring; Melatonin; Metabolism; Shift work
Depositing User : Clive Harris
Date Deposited : 16 Aug 2019 12:27
Last Modified : 07 Aug 2020 02:08
URI: http://epubs.surrey.ac.uk/id/eprint/852424

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800