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Vitamin D deficiency and effects of vitamin D supplementation on disease severity in patients with Atopic Dermatitis: a systematic review and meta-analysis in adults and children

Hattangdi-Haridas, Sonal R., Lanham-New, Susan A., Wong, Wilfred Hing Sang, Ho, Marco Hok Kung and Darling, Andrea L. (2019) Vitamin D deficiency and effects of vitamin D supplementation on disease severity in patients with Atopic Dermatitis: a systematic review and meta-analysis in adults and children Nutrients, 11 (8), 1854. pp. 1-19.

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Abstract

Research has investigated 25-hydroxyvitamin D (25(OH)D) levels in the Atopic Dermatitis (AD) population, as well as changes in AD severity after vitamin D (VitD) supplementation. We performed an up-to-date systematic review and meta-analysis of these findings. Electronic searches of MEDLINE, EMBASE and COCHRANE up to February 2018 were performed. Observational studies comparing 25(OH)D between AD patients and controls, as well as trials documenting baseline serum 25(OH)D levels and clinical severity by either SCORAD/EASI scores, were included. Of 1085 articles retrieved, sixteen were included. A meta-analysis of eleven studies of AD patients vs. healthy controls (HC) found a mean difference of -14 nmol/L (95%CI -25 to -2) for all studies and -16 nmol/L (95% CI -31 to -1) for the paediatric studies alone. A meta-analysis of three VitD supplementation trials found lower SCORAD by -11 points (95% CI -13 to -9) (p ˂0·00001). This surpasses the Minimal Clinical Important Difference for AD of 9.0 points (by 22%). There were greater improvements in trials lasting three months and the mean weighted dose of all trials was 1500-1600U/day. Overall, the AD population, especially the paediatric subset, may be at high-risk for lower serum 25(OH)D. Supplementation with around 1600IU/d results in a clinically meaningful AD severity reduction.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Hattangdi-Haridas, Sonal R.
Lanham-New, Susan A.S.Lanham-New@surrey.ac.uk
Wong, Wilfred Hing Sang
Ho, Marco Hok Kung
Darling, Andrea L.A.L.Darling@surrey.ac.uk
Date : 9 August 2019
DOI : 10.3390/nu11081854
Copyright Disclaimer : © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Uncontrolled Keywords : Hydroxyvitamin D; 25(OH)D; Systematic Review; Case-control; Supplementation; Meta-analysis; Atopic Dermatitis; Paediatric; Randomised Control Trial; SCORAD
Depositing User : Clive Harris
Date Deposited : 08 Aug 2019 11:02
Last Modified : 21 Aug 2019 07:44
URI: http://epubs.surrey.ac.uk/id/eprint/852376

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