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Suction filling of pharmaceutical powders

Zakhvatayeva, Anastasiya, Hare, Colin and Wu, Chuan-Yu (2019) Suction filling of pharmaceutical powders Powder Technology.

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Abstract

Die filling is an important process step in manufacturing of tablets. An important mechanism in the die filling process is suction that is developed with the downward motion of the bottom punch once the die is covered by powder. However, the contribution of suction to the die filling performance is still poorly understood. Hence, the present study aimed to experimentally investigate the flow behaviour of powders during suction filling. Four different types of pharmaceutical powders were used and a model suction filling system was developed. Effects of filling and suction velocities, as well as powder properties, on the efficiency of die filling were systematically investigated. Cohesive and free-flowing powders behaved differently at various filling-to-suction velocity ratios. The filling behaviour of cohesive powders was improved at high filling-to-suction ratios due to acceleration-induced densification. Free-flowing powders performed better at low filling-to suction ratios.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
NameEmailORCID
Zakhvatayeva, Anastasiyaa.zakhvatayeva@surrey.ac.uk
Hare, Colinc.hare@surrey.ac.uk
Wu, Chuan-Yuc.y.wu@surrey.ac.uk
Date : 2019
Copyright Disclaimer : © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Die filling; Suction; Optimal velocity ratio; Plug flow; Tabletting; Powder flow
Related URLs :
Depositing User : Clive Harris
Date Deposited : 07 Aug 2019 08:02
Last Modified : 07 Aug 2019 08:02
URI: http://epubs.surrey.ac.uk/id/eprint/852361

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