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Age-related changes in B cells relevant to vaccine responses

Dunn-Walters, Deborah, Stewart, Alexander, Sinclair, Emma and Serangeli, Ilaria (2019) Age-related changes in B cells relevant to vaccine responses Interdisciplinary Topics in Gerontology and Geriatrics.

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Abstract

Older people have reduced immune responses to infection and vaccination. B cell activation is key for the efficacy of the vaccine response, but there are several age-related changes in B cells which may contribute to the loss of vaccine efficacy. Different subpopulations of B cells contain have different functions and phenotypes. These populations can change as we age; older people have been shown to have fewer “IgM memory” cells, regulatory B cells and plasma cells and more IgD-CD27- “double negative” and “Age-related B cells”. While the overall quantity of antibody in the blood does not change, the quality of the B cell response changes; producing less specific antibodies upon challenge and more autoreactive antibodies. This could be due to changes in selection pressures, as has been demonstrated by repertoire sequencing of different subsets of B cells at different ages. Other changes in antibody repertoire are seen, including: greater levels of IgG2 in older people, and altered IgG1 IGHV gene usage. Since B cells rely on their environment for efficient responses, some of these changes may be due to age-related changes in accessory cells/signals. Other changes appear to be intrinsic to older/aged B cells themselves, such as their tendency to produce greater levels of inflammatory cytokines.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Dunn-Walters, Deborahd.dunn-walters@surrey.ac.uk
Stewart, Alexanderalexander.stewart@surrey.ac.uk
Sinclair, Emmae.sinclair@surrey.ac.uk
Serangeli, Ilaria
Date : 2019
Copyright Disclaimer : © 2019 S. Karger AG, Basel
Related URLs :
Depositing User : Clive Harris
Date Deposited : 25 Jul 2019 07:40
Last Modified : 25 Jul 2019 07:40
URI: http://epubs.surrey.ac.uk/id/eprint/852305

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