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Scalable ultrasmall three-dimensional nanowire transistor probes for intracellular recording

Zhao, Yunlong, You, Siheng Sean, Zhang, Anqi, Lee, Jae-Hyun, Huang, Jinlin and Lieber, Charles M. (2019) Scalable ultrasmall three-dimensional nanowire transistor probes for intracellular recording Nature Nanotechnology. pp. 1-10.

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Abstract

New tools for intracellular electrophysiology that push the limits of spatiotemporal resolution while reducing invasiveness could provide a deeper understanding of electrogenic cells and their networks in tissues, and push progress towards human–machine interfaces. Although significant advances have been made in developing nanodevices for intracellular probes, current approaches exhibit a trade-off between device scalability and recording amplitude. We address this challenge by combining deterministic shape-controlled nanowire transfer with spatially defined semiconductor-to-metal transformation to realize scalable nanowire field-effect transistor probe arrays with controllable tip geometry and sensor size, which enable recording of up to 100 mV intracellular action potentials from primary neurons. Systematic studies on neurons and cardiomyocytes show that controlling device curvature and sensor size is critical for achieving high-amplitude intracellular recordings. In addition, this device design allows for multiplexed recording from single cells and cell networks and could enable future investigations of dynamics in the brain and other tissues.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering
Authors :
NameEmailORCID
Zhao, Yunlongyunlong.zhao@surrey.ac.uk
You, Siheng Sean
Zhang, Anqi
Lee, Jae-Hyun
Huang, Jinlin
Lieber, Charles M.
Date : 1 July 2019
DOI : 10.1038/s41565-019-0478-y
Copyright Disclaimer : © The Author(s), under exclusive licence to Springer Nature Limited 2019
Depositing User : Clive Harris
Date Deposited : 08 Jul 2019 09:20
Last Modified : 08 Jul 2019 09:22
URI: http://epubs.surrey.ac.uk/id/eprint/852217

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