Head Start Immunity: Characterising the early protection of C strain vaccine against subsequent classical swine fever virus infection

McCarthy, Ronan R., Everett, Helen E., Graham, Simon P., Steinbach, Falko and Crooke, Helen R. (2019) Head Start Immunity: Characterising the early protection of C strain vaccine against subsequent classical swine fever virus infection Frontiers In Immunology.

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Abstract

Classical Swine Fever Virus (CSFV) is an ongoing threat to the pig industry due to its high transmission and mortality rates associated with infection. Live attenuated vaccines such as the CSFV C strain vaccine are capable of protecting against infection within 5 days of vaccination, but the molecular mechanisms through which this early protection is mediated have yet to be established. In this study, we compared the response of pigs vaccinated with the C strain to non-vaccinated pigs both challenged with a pathogenic strain of CSFV. Analysis of transcriptomic data from the tonsils of these animals during the early stages after vaccination and challenge reveals a set of regulated genes that appear throughout the analysis. Many of these are linked to the ISG15 antiviral pathway suggesting it plays a key role in the rapid and early protection conferred by C strain vaccination.

Item Type:	Article
Divisions :	Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :	Name Email ORCID McCarthy, Ronan R. Everett, Helen E. Graham, Simon P. s.graham@surrey.ac.uk Steinbach, Falko f.steinbach@surrey.ac.uk Crooke, Helen R.
Date :	2019
Funders :	Department for Environment, Food and Rural Affairs, Scottish Government, Welsh Government
DOI :	10.3389/fimmu.2019.01584
Copyright Disclaimer :	© 2019 McCarthy, Everett, Graham, Steinbach and Crooke. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Uncontrolled Keywords :	CSFV; C strain; ISG15; Antiviral; Vaccination; Innate immunity; Classical Swine Fever
Depositing User :	Clive Harris
Date Deposited :	01 Jul 2019 12:26
Last Modified :	07 Oct 2019 10:05
URI:	http://epubs.surrey.ac.uk/id/eprint/852187

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