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Heritability of semantic verbal fluency task using time-interval analysis

Taporoski, T. P., Duarte, N.E., Pompéia, S., Sterr, A., Gómez, L.M., Alvim, R.O., Horimoto, A.R.V.R., Krieger, J.E., Vallada, H., Pereira, A.C. , von Schantz, M. and Negrão, A.B. (2019) Heritability of semantic verbal fluency task using time-interval analysis PLOS ONE, 14 (6), e0217814. pp. 1-13.

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Abstract

Individual variability in word generation is a product of genetic and environmental influences. The genetic effects on semantic verbal fluency were estimated in 1,735 participants from the Brazilian Baependi Heart Study. The numbers of exemplars produced in 60 s were broken down into time quartiles because of the involvement of different cognitive processes — predominantly automatic at the beginning, controlled/executive at the end. Heritability in the unadjusted model for the 60-s measure was 0.32. The best-fit model contained age, sex, years of schooling, and time of day as covariates, giving a heritability of 0.21. Schooling had the highest moderating effect. The highest heritability (0.17) was observed in the first quartile, decreasing to 0.09, 0.12, and 0.0003 in the following ones. Heritability for average production starting point (intercept) was 0.18, indicating genetic influences for automatic cognitive processes. Production decay (slope), indicative of controlled processes, was not significant. The genetic influence on different quartiles of the semantic verbal fluency test could potentially be exploited in clinical practice and genome-wide association studies.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Taporoski, T. P.
Duarte, N.E.
Pompéia, S.
Sterr, A.A.Sterr@surrey.ac.uk
Gómez, L.M.
Alvim, R.O.
Horimoto, A.R.V.R.
Krieger, J.E.
Vallada, H.
Pereira, A.C.
von Schantz, M.M.Von.Schantz@surrey.ac.uk
Negrão, A.B.
Date : 11 June 2019
DOI : 10.1371/journal.pone.0217814
Copyright Disclaimer : © 2019 Taporoski et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related URLs :
Depositing User : Clive Harris
Date Deposited : 10 Jun 2019 09:30
Last Modified : 13 Jun 2019 07:18
URI: http://epubs.surrey.ac.uk/id/eprint/851963

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