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Strategies for optimising musculoskeletal health in the 21st century

Lewis, Rebecca, Gomez Alvarez, Constanza B., Rayman, Margaret, Lanham-New, Susan, Woolf, Anthony and Mobasheri, Ali (2019) Strategies for optimising musculoskeletal health in the 21st century BMC Musculoskeletal Disorders, 20, 164. pp. 1-15.

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We live in a world with an ever-increasing ageing population. Studying healthy ageing and reducing the socioeconomic impact of age-related diseases is a key research priority for the industrialised and developing countries, along with a better mechanistic understanding of the physiology and pathophysiology of ageing that occurs in a number of age-related musculoskeletal disorders. Arthritis and musculoskeletal disorders constitute a major cause of disability and morbidity globally and result in enormous costs for our health and social-care systems.

By gaining a better understanding of healthy musculoskeletal ageing and the risk factors associated with premature ageing and senescence, we can provide better care and develop new and better-targeted therapies for common musculoskeletal disorders. This review is the outcome of a two-day multidisciplinary, international workshop sponsored by the Institute of Advanced Studies entitled “Musculoskeletal Health in the 21st Century” and held at the University of Surrey from 30th June-1st July 2015.

The aim of this narrative review is to summarise current knowledge of musculoskeletal health, ageing and disease and highlight strategies for prevention and reducing the impact of common musculoskeletal diseases.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
Gomez Alvarez, Constanza
Woolf, Anthony
Date : 11 April 2019
Funders : University of Surrey
DOI : 10.1186/s12891-019-2510-7
Copyright Disclaimer : © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Uncontrolled Keywords : Ageing; Musculoskeletal health; Musculoskeletal disorders; Global burden; Joint diseases; Osteoarthritis (OA); Rheumatoid arthritis (RA); Low back pain (LBP); Osteoporosis (OP); Sarcopenia; Obesity; Type II diabetes; Metabolic disease
Depositing User : Clive Harris
Date Deposited : 10 May 2019 13:46
Last Modified : 10 May 2019 13:46

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