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Effect of Acute Total Sleep Deprivation on Plasma Melatonin, Cortisol and Metabolite Rhythms in Females

Honma, Aya, Revell, Victoria L., Gunn, Pippa J., Davies, Sarah K., Middleton, Benita, Raynaud, Florence I. and Skene, Debra J. (2019) Effect of Acute Total Sleep Deprivation on Plasma Melatonin, Cortisol and Metabolite Rhythms in Females European Journal of Neuroscience.

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Abstract

Disruption to sleep and circadian rhythms can impact on metabolism. The study aimed to investigate the effect of acute sleep deprivation on plasma melatonin, cortisol and metabolites, to increase understanding of the metabolic pathways involved in sleep/wake regulation processes. Twelve healthy young female subjects remained in controlled laboratory conditions for ~92 h with respect to posture, meals and environment light (18:00‐23:00 h and 07:00‐09:00 h <8 lux; 23:00‐07:00 h 0 lux (sleep opportunity) or <8 lux (continuous wakefulness); 09:00‐18:00 h ~ 90 lux). Regular blood samples were collected for 70 h for plasma melatonin and cortisol, and targeted liquid chromatography‐mass spectrometry metabolomics. Timepoints between 00:00 and 06:00 h for day 1 (baseline sleep), day 2 (sleep deprivation) and day 3 (recovery sleep) were analysed. Cosinor analysis and MetaCycle analysis were performed for detection of rhythmicity. Night time melatonin levels were significantly increased during sleep deprivation and returned to baseline levels during recovery sleep. No significant differences were observed in cortisol levels. Of 130 plasma metabolites quantified, 41 metabolites were significantly altered across the study nights, with the majority decreasing during sleep deprivation, most notably phosphatidylcholines. In cosinor analysis, 58 metabolites maintained their rhythmicity across the study days, with the majority showing a phase advance during acute sleep deprivation. This observation differs to that previously reported for males. Our study is the first of metabolic profiling in females during sleep deprivation and recovery sleep, and offers a novel view of human sleep/wake regulation and sex differences.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Honma, Aya
Revell, Victoria L.
Gunn, Pippa J.
Davies, Sarah K.
Middleton, BenitaB.Middleton@surrey.ac.uk
Raynaud, Florence I.
Skene, Debra J.D.Skene@surrey.ac.uk
Date : 30 March 2019
Funders : Biotechnology and Biological Sciences Research Council (BBSRC)
DOI : 10.1111/ejn.14411
Copyright Disclaimer : © 2019 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords : Metabolomics; Circadian rhythms; Sleep biomarkers; Humans
Depositing User : Clive Harris
Date Deposited : 29 Apr 2019 13:43
Last Modified : 31 Mar 2020 02:08
URI: http://epubs.surrey.ac.uk/id/eprint/851712

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