University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Molecular systems biology of sic1 in yeast cell cycle regulation through multiscale modeling

Barberis, Matteo (2012) Molecular systems biology of sic1 in yeast cell cycle regulation through multiscale modeling In: Advances in Systems Biology. Advances in Experimental Medicine and Biology, 736 (736). Springer, New York, NY, pp. 135-167. ISBN 00652598 (ISSN); 978-1-4419-7209-5 (ISBN)

Full text not available from this repository.

Abstract

Cell cycle control is highly regulated to guarantee the precise timing of events essential for cell growth, i.e., DNA replication onset and cell division. Failure of this control plays a role in cancer and molecules called cyclin-dependent kinase (Cdk) inhibitors (Ckis) exploit a critical function in cell cycle timing. Here we present a multiscale modeling where experimental and computational studies have been employed to investigate structure, function and temporal dynamics of the Cki Sic1 that regulates cell cycle progression in Saccharomyces cerevisiae. Structural analyses reveal molecular details of the interaction between Sic1 and Cdk/cyclin complexes, and biochemical investigation reveals Sic1 function in analogy to its human counterpart p27Kip1, whose deregulation leads to failure in timing of kinase activation and, therefore, to cancer. Following these findings, a bottom-up systems biology approach has been developed to characterize modular networks addressing Sic1 regulatory function. Through complementary experimentation and modeling, we suggest a mechanism that underlies Sic1 function in controlling temporal waves of cyclins to ensure correct timing of the phase-specific Cdk activities. © 2012 Springer Science+Business Media, LLC.

Item Type: Book Section
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Barberis, Matteom.barberis@surrey.ac.uk
Date : 2012
DOI : 10.1007/978-1-4419-7210-1_7
Uncontrolled Keywords : Cell Cycle Progression; Granulosa Cell Tumor; Phase Onset; Fluorescence Lifetime Imaging Microscopy; Regulate Cell Cycle Progression
Depositing User : Clive Harris
Date Deposited : 12 Apr 2019 13:42
Last Modified : 12 Apr 2019 13:42
URI: http://epubs.surrey.ac.uk/id/eprint/851018

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800