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Bench-to-bedside review: Inhaled nitric oxide therapy in adults.

Creagh-Brown, Benedict C., Griffiths, M.J. and Evans, T.W. (2009) Bench-to-bedside review: Inhaled nitric oxide therapy in adults. Critical care, 13 (3), 221. pp. 1-8.

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Nitric oxide (NO) is an endogenous mediator of vascular tone and host defence. Inhaled nitric oxide (iNO) results in preferential pulmonary vasodilatation and lowers pulmonary vascular resistance. The route of administration delivers NO selectively to ventilated lung units so that its effect augments that of hypoxic pulmonary vasoconstriction and improves oxygenation. This 'Bench-to-bedside' review focuses on the mechanisms of action of iNO and its clinical applications, with emphasis on acute lung injury and the acute respiratory distress syndrome. Developments in our understanding of the cellular and molecular actions of NO may help to explain the hitherto disappointing results of randomised controlled trials of iNO.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Creagh-Brown, Benedict
Griffiths, M.J.
Evans, T.W.
Date : 29 May 2009
DOI : 10.1186/cc7734
Copyright Disclaimer : © BioMed Central Ltd 2009
Uncontrolled Keywords : Nitric Oxide; Acute Lung Injury; Right Ventricle; Acute Respiratory Distress Syndrome; Pulmonary Vascular Resistance
Depositing User : Clive Harris
Date Deposited : 22 Mar 2019 13:42
Last Modified : 22 Mar 2019 13:42

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