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Association between preoperative plasma sRAGE levels and recovery from cardiac surgery

Creagh-Brown, Benedict C., Quinlan, G.J., Hector, L.R., Evans, T.W. and Burke-Gaffney, A. (2013) Association between preoperative plasma sRAGE levels and recovery from cardiac surgery Mediators of Inflammation, 2013, 496031.

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Abstract

Background. The receptor for advanced glycation end products (RAGE) is an inflammation-perpetuating receptor, and soluble RAGE (sRAGE) is a marker of cellular RAGE expression. This study investigated whether raised plasma levels prior to surgery of sRAGE or S100A8/A9 (a RAGE ligand) were associated with longer duration of hospital care in patients undergoing cardiac surgery necessitating cardiopulmonary bypass.

Methods. Patients (n=130) undergoing elective cardiac surgery were enrolled prospectively. Plasma sRAGE and S100A8/A9 concentrations were measured before and 2 h after surgery.

Results. Preoperative plasma sRAGE increased significantly (P˂0.0001) from 1.06 ng/mL (IQR, 0.72-1.76) to 1.93 ng/mL (IQR, 1.14-2.63) 2 h postoperatively. Plasma S100A8/9 was also significantly (P˂0.0001) higher 2 h postoperatively (2.37 g/mL, IQR, 1.81-3.05) compared to pre-operative levels (0.41 g/mL, IQR, 0.2-0.65). Preoperative sRAGE, but not S100A8/A9, was positively and significantly correlated with duration of critical illness (r=0.3, P=0.0007) and length of hospital stay (LOS; r=0.31, P˂0.0005). Multivariate binary logistic regression showed preoperative sRAGE to be, statistically, an independent predictor of greater than median duration of critical illness (odds ratio 16.6, P=0.014) and to be, statistically, the strongest independent predictor of hospital LOS.

Conclusion. Higher preoperative plasma sRAGE levels were associated with prolonged duration of care in adults undergoing cardiac surgery requiring cardiopulmonary bypass.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Creagh-Brown, Benedict C.b.creagh-brown@surrey.ac.uk
Quinlan, G.J.
Hector, L.R.
Evans, T.W.
Burke-Gaffney, A.
Date : 2013
Funders : Wellcome Trust, British Heart Foundation, National Institute for Health Research (NIHR)
DOI : 10.1155/2013/496031
Copyright Disclaimer : Copyright © 2013 Benedict C. Creagh-Brown et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Depositing User : Clive Harris
Date Deposited : 20 Mar 2019 12:07
Last Modified : 20 Mar 2019 12:07
URI: http://epubs.surrey.ac.uk/id/eprint/850770

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