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Type 2 Diabetes and Asthma: Systematic Review of the Bidirectional Relationship

Rayner, Louise, Mcgovern, Andrew, Creagh-Brown, Ben, Woodmansey, Chris and de Lusignan, Simon (2019) Type 2 Diabetes and Asthma: Systematic Review of the Bidirectional Relationship Current diabetes reviews, 15 (2). pp. 118-126.

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Background and Objective: Obesity is an important contributor to the risk of both asthma and Type 2 Diabetes (T2DM). However, it has been suggested that T2DM and asthma are also independently associated. The aim of this systematic review was to synthesize the evidence for an independent relationship between T2DM and asthma.

Methods: MEDLINE and EMBASE were searched for studies reporting the relationship between asthma and T2DM in adults. Given a potential bidirectional relationship, articles relating to T2DM as a risk factor for asthma, and asthma as a risk factor for T2DM were examined separately.

Results: Eight studies were identified for inclusion in the review (n=2,934,399 participants). Four studies examined incident diabetes in those with asthma. The pooled (random effects model) adjusted hazard ratio for incident T2DM in asthma was 1.37 (95%CI 1.12-1.69; p ˂0.001) after controlling for BMI. Four studies reported prevalence or incidence rates of asthma in people with T2DM; higher rates of asthma in those with T2DM were reported in all four studies. Meta-analysis of results was not possible due to methodological heterogeneity. The quality of included studies was good, but due to small numbers, publication bias cannot be excluded.

Conclusion: The published literature suggests a bidirectional independent relationship between T2DM and asthma, although we cannot exclude publication bias.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Rayner, Louise
Woodmansey, Chris
de Lusignan,
Date : February 2019
DOI : 10.2174/1573399814666180711114859
Copyright Disclaimer : © 2018 Bentham Science Publishers
Uncontrolled Keywords : Asthma; Bidirectional relationship; BMI; Incidence; Obesity; Type 2 diabetes
Depositing User : Clive Harris
Date Deposited : 18 Mar 2019 10:26
Last Modified : 02 Jan 2020 02:08

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