University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Mon2 predicts poor outcome in ST-elevation myocardial infarction

Shantsila, E., Ghattas, A., Griffiths, H. R. and Lip, G. Y. H. (2019) Mon2 predicts poor outcome in ST-elevation myocardial infarction Journal of Internal Medicine, 285 (3). pp. 301-316.

[img] Text
Mon2 predicts poor outcome in ST-elevation myocardial infarction.pdf - Version of Record
Restricted to Repository staff only

Download (4MB)

Abstract

Aims

There are limited data on the role of human monocyte subsets in ST‐elevation myocardial infarction (STEMI). The study aimed to establish the relationship between monocyte subsets, their phagocytic and nuclear factor κB (NFκB) activity and outcomes in STEMI.

Methods

Monocyte subsets and their phagocytic activity and intracellular levels of inhibitory κB kinase β (IKKβ, marker of NFκB activity) were measured by flow cytometry in 245 patients with STEMI, median follow‐up of 46 months.

Results

Mon2 (CD14++CD16+CCR2+) counts were independently predictive of major adverse cardiovascular events (MACE) [4th quartile HR 3.42 (95% CI 1.43–8.16), P = 0.006 and 3rd quartile HR 2.88 (95% CI 1.19–7.00), P = 0.02 vs. 1st quartile]. Mon2 subset was the only subset associated with higher occurrence of heart failure (4th quartile vs. 1st quartile, sevenfold, P = 0.001 on univariate analysis; fivefold, P = 0.04 on multivariable analysis). On receiver operating characteristic, analysis including of Mon2 improved prognostic value of troponin T and creatine kinase for MACE and heart failure (HF). Higher intracellular Mon2 IKKβ levels were associated with 10‐fold lower occurrence of HF on multivariable analysis (4th vs. 1st quartiles, P = 0.03). Abnormal Mon1 and Mon2 phagocytic capacities were related to HF development, but the association was dependent on the infarct size and other prognosticators. High Mon2 levels were associated with lower ejection fraction after STEMI onset (P = 0.001) and at 6‐month follow‐up (P ˂ 0.001).

Conclusions

Abnormal Mon2 characteristics have a unique association with poor outcome in patients with STEMI. The relation of Mon2 with occurrence of HF is strongly and independently related to their functional status, which may have potential therapeutic implications.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Shantsila, E.
Ghattas, A.
Griffiths, H. R.h.r.griffiths@surrey.ac.uk
Lip, G. Y. H.
Date : 15 January 2019
Funders : Heart Research UK
DOI : 10.1111/joim.12847
Copyright Disclaimer : © 2019 The Association for the Publication of the Journal of Internal Medicine
Uncontrolled Keywords : Ejection fraction; Monocyte subsets; Myocardial infarction; Phagocytosis
Depositing User : Clive Harris
Date Deposited : 15 Mar 2019 14:39
Last Modified : 22 Nov 2019 12:45
URI: http://epubs.surrey.ac.uk/id/eprint/850742

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800