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Circulating anthocyanin metabolites mediate vascular benefits of blueberries: insights from randomized controlled trials, metabolomics, and nutrigenomics

Rodriguez-Mateos, Ana, Istas, Geoffrey, Boschek, Lisa, Feliciano, Rodrigo P, Mills, Charlotte E, Boby, Céline, Gomez-Alonso, Sergio, Milenkovic, Dragan and Heiss, Christian (2019) Circulating anthocyanin metabolites mediate vascular benefits of blueberries: insights from randomized controlled trials, metabolomics, and nutrigenomics The Journals of Gerontology: Series A, 74 (7). p 967-976.

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Abstract

Potential health benefits of blueberries may be due to vascular effects of anthocyanins which predominantly circulate in blood as phenolic acid metabolites. We investigated which role blueberry anthocyanins and circulating metabolites play in mediating improvements in vascular function and explore potential mechanisms using metabolomics and nutrigenomics. Purified anthocyanins exerted a dose-dependent improvement of endothelial function in healthy humans, as measured by flow-mediated dilation (FMD). The effects were similar to those of blueberries containing similar amounts of anthocyanins while control drinks containing fiber, minerals, or vitamins had no significant effect. Daily 1-month blueberry consumption increased FMD and lowered 24h-ambulatory-systolic-blood-pressure. Of the 63 anthocyanin plasma metabolites quantified, 14 and 17 correlated with acute and chronic FMD improvements, respectively. Injection of these metabolites improved FMD in mice. Daily blueberry consumption led to differential expression (>1.2-fold) of 608 genes and 3 microRNAs, with Mir-181c showing a 13-fold increase in peripheral blood mononuclear cells. Patterns of 13 metabolites were independent predictors of gene expression changes and pathway enrichment analysis revealed significantly modulated biological processes involved in cell adhesion, migration, immune response, and cell differentiation. Our results identify anthocyanin metabolites as major mediators of vascular bioactivities of blueberries and changes of cellular gene programs.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Rodriguez-Mateos, Anaa.rodriguez-mateos@surrey.ac.uk
Istas, Geoffrey
Boschek, Lisa
Feliciano, Rodrigo P
Mills, Charlotte E
Boby, Céline
Gomez-Alonso, Sergio
Milenkovic, Dragan
Heiss, Christianc.heiss@surrey.ac.uk
Date : July 2019
DOI : 10.1093/gerona/glz047
Copyright Disclaimer : © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
Uncontrolled Keywords : Polyphenols; Blueberries; Endothelial function; Omics; Nutrition; Metabolomics
Depositing User : Clive Harris
Date Deposited : 05 Mar 2019 09:54
Last Modified : 17 Feb 2020 02:08
URI: http://epubs.surrey.ac.uk/id/eprint/850663

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