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Chronic sleep restriction in the rotenone Parkinson’s disease model in rats reveals peripheral early-phase biomarkers

Fagotti, Juliane, Targa, Adriano D. S., Rodrigues, Lais S., Noseda, Ana Carolina D., Dorieux, Flávia W. C., Scarante, Franciele F., Ilkiw, Jessica L., Louzada, Fernando M., Chowdhury, Namrata, Van Der Veen, Daan , Middleton, Benita, Pennings, Jeroen L. A., Swann, Jonathan R., Skene, Debra and Lima, Marcelo M. S. (2019) Chronic sleep restriction in the rotenone Parkinson’s disease model in rats reveals peripheral early-phase biomarkers Scientific Reports, 9 (1), 1898.

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Abstract

Parkinson’s disease (PD) is a chronic disorder that presents a range of premotor signs, such as sleep disturbances and cognitive decline, which are key non-motor features of the disease. Increasing evidence of a possible association between sleep disruption and the neurodegenerative process suggests that sleep impairment could produce a detectable metabolic signature on the disease. In order to integrate neurocognitive and metabolic parameters, we performed untargeted and targeted metabolic profiling of the rotenone PD model in a chronic sleep restriction (SR) (6 h/day for 21 days) condition. We found that SR combined with PD altered several behavioural (reversal of locomotor activity impairment; cognitive impairment; delay of rest-activity rhythm) and metabolic parameters (branched-chain amino acids, tryptophan pathway, phenylalanine, and lipoproteins, pointing to mitochondrial impairment). If combined, our results bring a plethora of parameters that represents reliable early-phase PD biomarkers which can easily be measured and could be translated to human studies.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Fagotti, Juliane
Targa, Adriano D. S.
Rodrigues, Lais S.
Noseda, Ana Carolina D.
Dorieux, Flávia W. C.
Scarante, Franciele F.
Ilkiw, Jessica L.
Louzada, Fernando M.
Chowdhury, Namratanamrata.chowdhury@surrey.ac.uk
Van Der Veen, DaanD.Vanderveen@surrey.ac.uk
Middleton, BenitaB.Middleton@surrey.ac.uk
Pennings, Jeroen L. A.
Swann, Jonathan R.
Skene, DebraD.Skene@surrey.ac.uk
Lima, Marcelo M. S.
Date : 13 February 2019
Funders : the Newton Fund, RCUK
DOI : 10.1038/s41598-018-37657-6
Copyright Disclaimer : © The Author(s) 2019
Depositing User : Diane Maxfield
Date Deposited : 28 Feb 2019 15:09
Last Modified : 28 Feb 2019 15:09
URI: http://epubs.surrey.ac.uk/id/eprint/850588

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