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Similarities and differences of dietary and other determinants of iodine status in pregnant women from three European birth cohorts

Dineva, Mariana, Rayman, Margaret P., Levie, Deborah, Guxens, Mònica, Peeters, Robin P., Vioque, Jesus, González, Llúcia, Espada, Mercedes, Ibarluzea, Jesús, Sunyer, Jordi , Korevaar, Tim I. M. and Bath, Sarah C. (2019) Similarities and differences of dietary and other determinants of iodine status in pregnant women from three European birth cohorts European Journal of Nutrition. pp. 1-17.

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Abstract

Purpose As a component of thyroid hormones, adequate iodine intake is essential during pregnancy for fetal neurodevelopment. Across Europe, iodine deficiency is common in pregnancy, but data are lacking on the predictors of iodine status at this life stage. We, therefore, aimed to explore determinants of iodine status during pregnancy in three European populations of differing iodine status. Methods Data were from 6566 pregnant women from three prospective population-based birth cohorts from the United Kingdom (ALSPAC, n = 2852), Spain (INMA, n = 1460), and The Netherlands (Generation R, n = 2254). Urinary iodine-to-creatinine ratio (UI/Creat, µg/g) was measured in spot-urine samples in pregnancy (≤ 18-weeks gestation). Maternal dietary intake, categorised by food groups (g/day), was estimated from food-frequency questionnaires (FFQs). Multivariable regression models used dietary variables (energy-adjusted) and maternal characteristics as predictors of iodine status. Results Median UI/Creat in pregnant women of ALSPAC, INMA, and Generation R was 121, 151, and 210 µg/g, respectively. Maternal age was positively associated with UI/Creat in all cohorts (P ˂ 0.001), while UI/Creat varied by ethnicity only in Generation R (P ˂ 0.05). Of the dietary predictors, intake of milk and dairy products (per 100 g/day) was positively associated with UI/Creat in all cohorts [ALSPAC (B = 3.73, P ˂ 0.0001); INMA (B = 6.92, P = 0.002); Generation R (B = 2.34, P = 0.001)]. Cohort-specific dietary determinants positively associated with UI/Creat included fish and shellfish in ALSPAC and INMA, and eggs and cereal/cereal products in Generation R. Conclusions The cohort-specific dietary determinants probably reflect not only dietary habits but iodine-fortification policies; hence, public-health interventions to improve iodine intake in pregnancy need to be country-specific.

Item Type: Article
Authors :
NameEmailORCID
Dineva, Marianam.dineva@surrey.ac.uk
Rayman, Margaret P.M.Rayman@surrey.ac.uk
Levie, Deborah
Guxens, Mònica
Peeters, Robin P.
Vioque, Jesus
González, Llúcia
Espada, Mercedes
Ibarluzea, Jesús
Sunyer, Jordi
Korevaar, Tim I. M.
Bath, Sarah C.s.bath@surrey.ac.uk
Date : 8 February 2019
Funders : Medical Research Council (MRC), Wellcome Trust
DOI : 10.1007/s00394-019-01913-w
Copyright Disclaimer : © Springer-Verlag GmbH Germany, part of Springer Nature 2019
Depositing User : Clive Harris
Date Deposited : 25 Feb 2019 11:54
Last Modified : 25 Feb 2019 11:54
URI: http://epubs.surrey.ac.uk/id/eprint/850562

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