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Antimicrobial Resistance on Farms: A Review Including Biosecurity and the Potential Role of Disinfectants in Resistance Selection

Davies, Robert and Wales, Andrew (2019) Antimicrobial Resistance on Farms: A Review Including Biosecurity and the Potential Role of Disinfectants in Resistance Selection Comprehensive Reviews in Food Science and Food Safety, 18 (3). pp. 753-774.

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Abstract

Resistance to therapeutic antimicrobial agents is recognized as a growing problem for both human and veterinary medicine, and the need to address the issue in both of these linked domains is a current priority in public policy. Efforts to limit antimicrobial resistance on farms has so far focused on control of the supply and use of antimicrobial drugs, plus husbandry measures to reduce infectious disease. In the United Kingdom (UK) and some other countries, substantial progress has been made recently against targets on agricultural antimicrobial drug use. However, evidence suggests that resistant pathogenic and commensal bacteria can persist and spread within and between premises despite declining or zero antimicrobial drug use. Reasons for this are likely complex and varied but may include: bacterial adaptations to ameliorate fitness costs associated with maintenance and replication of resistance genes and associated proteins, horizontal transmission of genetic resistance determinants between bacteria, physical transfer of bacteria via movement (of animals, workers, and equipment), ineffective cleaning and disinfection, and coselection of resistance to certain drugs by use of other antimicrobials, heavy metals, or biocides. Areas of particular concern for public health include extended-spectrum cephalosporinases and fluoroquinolone resistance among Enterobacteriaceae, livestock-associated methicillin-resistant Staphylococcus aureus, and the emergence of transmissible colistin resistance. Aspects of biosecurity have repeatedly been identified as risk factors for the presence of antimicrobial resistance on farm premises, but there are large gaps in our understanding of the most important risk factors and the most effective interventions. The present review aims to summarize the present state of knowledge in this area, from a European perspective.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Davies, Robert
Wales, Andrewa.wales@surrey.ac.uk
Date : May 2019
Funders : Department for Environment, Food and Rural Affairs
DOI : 10.1111/1541-4337.12438
Grant Title : Surveillance project FZ2000
Copyright Disclaimer : © 2019 Institute of Food Technologists® This is the peer reviewed version of the following article: Davies, R. and Wales, A. (2019), 'Antimicrobial Resistance on Farms: A Review Including Biosecurity and the Potential Role of Disinfectants in Resistance Selection'. Comprehensive Reviews in Food Science and Food Safety, 18: 753-774, which has been published in final form at https://doi.org/10.1111/1541-4337.12438 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. No further action
Uncontrolled Keywords : Antimicrobial; Resistance; Biosecurity; Hygiene; Livestock
Depositing User : Clive Harris
Date Deposited : 22 Feb 2019 12:40
Last Modified : 02 Jul 2019 08:44
URI: http://epubs.surrey.ac.uk/id/eprint/850552

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