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Primed to Sleep: The Dynamics of Synaptic Plasticity Across Brain States

Seibt, Julie and Frank, Marcos G (2019) Primed to Sleep: The Dynamics of Synaptic Plasticity Across Brain States Frontiers in Neuroscience.

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Abstract

It is commonly accepted that brain plasticity occurs in wakefulness and sleep. However, how these different brain states work in concert to create long-lasting changes in brain circuitry is unclear. Considering that wakefulness and sleep are profoundly different brain states on multiple levels (e.g., cellular, molecular and network activation), it is unlikely that they operate exactly the same way. Rather it is probable that they engage different, but coordinated, mechanisms. In this article we discuss how plasticity may be divided across the sleep–wake cycle, and how synaptic changes in each brain state are linked. Our working model proposes that waking experience triggers short-lived synaptic events that are necessary for transient plastic changes and mark (i.e., ‘prime’) circuits and synapses for further processing in sleep. During sleep, synaptic protein synthesis at primed synapses leads to structural changes necessary for long-term information storage.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Seibt, Juliej.seibt@surrey.ac.uk
Frank, Marcos G
Date : 1 February 2019
Funders : University of Surrey/Braithwaites Foundation, Wellcome Trust, National Institutes of Health
DOI : 10.3389/fnsys.2019.00002
Copyright Disclaimer : © 2019 Seibt and Frank. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Uncontrolled Keywords : Sleep; Experience; Plasticity; Tagging; Excitability; Priming; Consolidation
Depositing User : Diane Maxfield
Date Deposited : 18 Feb 2019 12:12
Last Modified : 18 Feb 2019 12:12
URI: http://epubs.surrey.ac.uk/id/eprint/850454

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