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The chemical constituents of Penianthus longifolius Miers

Tabekoueng, Georges Bellier, Akak, Carine Mvot, Langat, Moses K., Blaise Azebaze, Anatole Guy, Kamdem Waffo, Alain Francois, Mulholland, Dulcie A. and Vardamides, Juliette Catherine (2019) The chemical constituents of Penianthus longifolius Miers Phytochemistry Letters, 30. pp. 103-106.

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Abstract

Fourteen compounds were isolated from the roots, leaves and twigs of Penianthus longifolius Miers (Menispermaceae), including two previously unreported neo-clerodane diterpenoids, penianthin (1), its C-8 epimer (2). In addition, the previously reported O-methylmoschatoline (3), taraxerol (4), taraxerone (5), rubrosterone, (6), panuosterone (7), 22-epi-20-hydroxyecdysone (8), ergosterol peroxide (9), stigmast-5-ene-3,7-dione (10), stigmasterol (11), β-sitosterol (12), stigmasterol glucoside (13) and β-sitosterol glucoside (14) were isolated. The structures of the compounds were determined by means of NMR spectroscopic and mass spectrometric analysis. The absolute configurations of 1 and 2 were determined by circular dichroism analysis. Compounds 1 and 2 were screened against the NCI60 cancer cell panel but showed no significant activity at 10 μM.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
NameEmailORCID
Tabekoueng, Georges Bellier
Akak, Carine Mvot
Langat, Moses K.ml0019@surrey.ac.uk
Blaise Azebaze, Anatole Guy
Kamdem Waffo, Alain Francois
Mulholland, Dulcie A.D.Mulholland@surrey.ac.uk
Vardamides, Juliette Catherine
Date : April 2019
DOI : 10.1016/j.phytol.2019.01.026
Copyright Disclaimer : © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Penianthus longifolius; Menispermaceae; Neo-clerodane diterpenoids; Penianthin; 8-epi-penianthin
Depositing User : Clive Harris
Date Deposited : 15 Feb 2019 10:06
Last Modified : 07 Feb 2020 02:08
URI: http://epubs.surrey.ac.uk/id/eprint/850435

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