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Vaccine development for Nipah virus infection in pigs

McLean, Rebecca K. and Graham, Simon P. (2019) Vaccine development for Nipah virus infection in pigs Frontiers in Veterinary Science.

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Abstract

Nipah virus (NiV) causes a severe and often fatal neurological disease in humans. Whilst fruit bats are considered the natural reservoir, NiV also infects pigs and may cause an unapparent or mild disease. Direct pig-to-human transmission was responsible for the first and still most devastating NiV outbreaks in Malaysia and Singapore in 1998-99, with nearly 300 human cases and over 100 fatalities. Pigs can therefore play a key role in the epidemiology of NiV by acting as an ‘amplifying’ host. The outbreak in Singapore ended with the prohibition of pig imports from Malaysia and the Malaysian outbreak was ended by culling 45% of the country’s pig population with costs exceeding US$500 million. Despite the importance of NiV as an emerging disease with the potential for pandemic, no vaccines or therapeutics are currently approved for human or livestock use. In this mini-review, we will discuss current knowledge of NiV infection in pigs; our ongoing work to develop a NiV vaccine for use in pigs; and the pig as a model to support human vaccine development.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
McLean, Rebecca K.
Graham, Simon P.s.graham@surrey.ac.uk
Date : 4 February 2019
DOI : 10.3389/fvets.2019.00016
Copyright Disclaimer : © 2019 McLean and Graham. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Contributors :
ContributionNameEmailORCID
http://www.loc.gov/loc.terms/relators/EDTJongkaewwattana, Anan
Uncontrolled Keywords : Nipah virus; Pigs; Zoonosis; Epidemiology; Pathogenesis; Vaccine development
Related URLs :
Depositing User : Clive Harris
Date Deposited : 31 Jan 2019 14:06
Last Modified : 05 Feb 2019 08:05
URI: http://epubs.surrey.ac.uk/id/eprint/850333

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