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Community exercise is feasible for neuromuscular diseases and can improve aerobic capacity

Wallace, Amanda, Pietrusz, Alexandra, Dewar, Elizabeth, Dudziec, Magdalena, Jones, Katherine, Hennis, Philip, Sterr, Annette, Baio, Gianluca, Machado, Pedro, Matilde, Laurá , Skorupinska, Iwona, Skorupinska, Mariola, Butcher, Karen, Trenell, Michael, Reilly, Mary M, Hanna, Michae and Ramdharry, Gita M (2019) Community exercise is feasible for neuromuscular diseases and can improve aerobic capacity Neurology, 92 (15). e1773-e1785.

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Abstract

Objective: The aim of this phase 2 trial was to ascertain the feasibility and effect of community based aerobic exercise training for people with two of the more common neuromuscular diseases: Charcot-Marie-Tooth disease type 1A (CMT) and Inclusion Body Myositis (IBM). Methods: A randomised single blinded cross over trial design was used to compare a 12-week aerobic training programme using recombinant exercise bicycles compared to a control period. The training occurred three times per week in community gyms local to the participants. Support was available from trained gym staff and a research physiotherapist. The two disease groups were analysed separately. The primary outcome measure was peak oxygen uptake (VO2 peak) during a maximal exercise test, with secondary measures of muscle strength, function and patient reported measures. Results: Data from 23 people with CMT and 17 people with IBM was included in the analysis. Both disease groups had high levels of participation and demonstrated improvements in VO2 peak, with a moderate effect size in the CMT participants (Cohen’s d = 0.53) and a strong effect size in the IBM group (Cohen’s d = 1.72). No major changes were observed in the secondary outcome measures. Qualitative interviews revealed that participants valued the support of gym instructors and the research physiotherapists in overcoming challenges to participation. Conclusion: Twelve weeks of aerobic training in community gyms was feasible, safe and improved aerobic capacity in people with CMT and IBM. Classification of Evidence: This study provides Class II evidence that for patients with CMT type 1A and IBM, an aerobic training program increases aerobic capacity.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Wallace, Amanda
Pietrusz, Alexandra
Dewar, Elizabeth
Dudziec, Magdalena
Jones, Katherine
Hennis, Philip
Sterr, AnnetteA.Sterr@surrey.ac.uk
Baio, Gianluca
Machado, Pedro
Matilde, Laurá
Skorupinska, Iwona
Skorupinska, Mariola
Butcher, Karen
Trenell, Michael
Reilly, Mary M
Hanna, Michae
Ramdharry, Gita M
Date : 8 April 2019
DOI : 10.1212/WNL.0000000000007265
Grant Title : Medical Research Council
Copyright Disclaimer : Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords : aerobic training; exercise; Charcot Marie Tooth disease; Inclusion Body Myositis; aerobic capacity; cardiopulmonary fitness
Depositing User : Rebecca Cooper
Date Deposited : 25 Jan 2019 09:27
Last Modified : 17 Apr 2019 10:49
URI: http://epubs.surrey.ac.uk/id/eprint/850277

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