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The cortisol awakening response at admission to hospital predicts depression severity after discharge in MDD patients

Eikeseth, Fillip F., Denninghaus, Sabrina, Cropley, Mark, Witthöft, Michael, Pawelzik, Markus and Sütterlin, Stefan (2019) The cortisol awakening response at admission to hospital predicts depression severity after discharge in MDD patients Journal of Psychiatric Research, 111. pp 45-50.

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The Cortisol Awakening Response at Admission to Hospital predicts Depression Severity After Discharge in MDD patients.docx - Accepted version Manuscript

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Major Depressive Disorder (MDD) is associated with hypothalamic-pituitary-adrenal axis (HPA) dysregulation and altered cortisol awakening response (CAR), a non-invasive biomarker for HPA axis reactivity. We theorized that the CAR resembles the accumulated effects of depression over time, and may therefore predict depressive symptom severity once patients return home following inpatient treatment. Two studies are reported. In Study 1 (n = 101; 57% female), the CAR was measured at intake and self-ratings of depression severity was assessed six weeks following discharge. Study 2 (n = 127; 58% female) was a replication and extension of Study 1 where a follow-up assessment of self-rated depression severity was added at six months following discharge. In Study 1 the CAR at intake showed a tendency towards a negative association with self-reported depression six weeks after discharge. Study 2 extended this finding within a more severely depressed, larger sample, where a blunted CAR predicted self-reported depressive severity six weeks and six month following discharge. These findings suggest that a blunted CAR can predict mood deterioration post treatment in inpatients diagnosed with severe MDD.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Psychology
Authors :
Eikeseth, Fillip F.
Denninghaus, Sabrina
Witthöft, Michael
Pawelzik, Markus
Sütterlin, Stefan
Date : 7 January 2019
DOI : 10.1016/j.jpsychires.2019.01.002
Copyright Disclaimer : © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Uncontrolled Keywords : Cortisol awakening response; Depression; HPA axis; Biomarker; Follow-up
Depositing User : Clive Harris
Date Deposited : 18 Jan 2019 11:01
Last Modified : 08 Jan 2020 02:08

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