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Effects of Ageing and Sex on Complexity in the Human Sleep EEG: A Comparison of Three Symbolic Dynamic Analysis Methods.

Tosun, Pinar Deniz, Dijk, Derk-Jan, Winsky-Sommerer, Raphaelle and Abasolo, Daniel (2019) Effects of Ageing and Sex on Complexity in the Human Sleep EEG: A Comparison of Three Symbolic Dynamic Analysis Methods. Complexity, 2019, 9254309. pp. 1-12.

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Abstract

Symbolic dynamic analysis (SDA) methods have been applied to biomedical signals and have been proven efficient in characterising differences in the electroencephalogram (EEG) in various conditions (e.g., epilepsy, Alzheimer’s, and Parkinson’s diseases). In this study, we investigated the use of SDA on EEGs recorded during sleep. Lempel-Ziv complexity (LZC), permutation entropy (PE), and permutation Lempel-Ziv complexity (PLZC), as well as power spectral analysis based on the fast Fourier transform (FFT), were applied to 8-h sleep EEG recordings in healthy men (n=31) and women (n=29), aged 20-74 years. The results of the SDA methods and FFT analysis were compared and the effects of age and sex were investigated. Surrogate data were used to determine whether the findings with SDA methods truly reflected changes in nonlinear dynamics of the EEG and not merely changes in the power spectrum. The surrogate data analysis showed that LZC merely reflected spectral changes in EEG activity, whereas PE and PLZC reflected genuine changes in the nonlinear dynamics of the EEG. All three SDA techniques distinguished the vigilance states (i.e., wakefulness, REM sleep, NREM sleep, and its sub-stages: stage 1, stage 2, and slow wave sleep). Complexity of the sleep EEG increased with ageing. Sex on the other hand did not affect the complexity values assessed with any of these three SDA methods, even though FFT detected sex differences. This study shows that SDA provides additional insights into the dynamics of sleep EEG and how it is affected by ageing.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Mechanical Engineering Sciences
Authors :
NameEmailORCID
Tosun, Pinar Denizp.tosun@surrey.ac.uk
Dijk, Derk-JanD.J.Dijk@surrey.ac.uk
Winsky-Sommerer, RaphaelleR.Winsky-Sommerer@surrey.ac.uk
Abasolo, DanielD.Abasolo@surrey.ac.uk
Date : 2 January 2019
Funders : Royal Society, Leverhulme Trust
DOI : 10.1155/2019/9254309
Grant Title : Wolfson Research Merit Award
Copyright Disclaimer : Copyright © 2019 Pinar Deniz Tosun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Contributors :
ContributionNameEmailORCID
http://www.loc.gov/loc.terms/relators/EDTNatella, Roberto
Depositing User : Clive Harris
Date Deposited : 17 Jan 2019 16:27
Last Modified : 06 Jul 2019 05:26
URI: http://epubs.surrey.ac.uk/id/eprint/850165

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