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Poor Sleep Quality and Lipid Profile in a Rural Cohort (The Baependi Heart Study).

Geovanini, Glaucylara Reis, Lorenzi-Filho, Geraldo, de Paula, Lilian K, Oliveira, Camila M, Alvim, Rafael O, Beijamini, Felipe, Negrão, André B, von Schantz, Malcolm, Knutson, Kristen L, Krieger, José E and Pereira, Alexandre C (2019) Poor Sleep Quality and Lipid Profile in a Rural Cohort (The Baependi Heart Study). Sleep Medicine, 57. pp. 30-35.

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Abstract

Aim: To test the association between cardiometabolic risk factors and subjective sleep quality assessed by the Pittsburgh sleep quality index (PSQI), independent of obstructive sleep apnea (OSA) and sleep duration.

Methods: 573 participants from the Baependi Heart Study, a rural cohort from Brazil that completed sleep questionnaires and underwent polygraphy for OSA evaluation. Multivariable linear regression analysis tested the association between cardiovascular risk factors (outcome variables) and sleep quality measured by PSQI, adjusting for OSA and other potential confounders (age, sex, race, salary/wage, education, marital status, alcohol intake, obesity, smoking, hypertension, and sleep duration).

Results: The sample mean age was of 43±16y, 66% were female, and mean body mass index (BMI) was 26±5 kg/m2. Only 20% were classified as obese (BMI ≥30). Fifty percent of participants reported poor sleep quality as defined by a PSQI score ≥5. A high PSQI score was significantly associated with higher very-low density lipoprotein (VLDL) cholesterol levels (beta=0.392, p=0.012) and higher triglyceride levels (beta=0.017, p=0.006), even after adjustments, including the apnea-hypopnea index. Further adjustments accounting for marital status, alcohol intake, and medication use did not change these findings. No significant association was observed between PSQI scores and glucose or blood pressure. According to PSQI components, sleep disturbances (beta=1.976, p=0.027), sleep medication use (beta=1.121, p=0.019), and daytime dysfunction (beta=1.290, p=0.024) were significantly associated with higher VLDL serum levels. Only the daytime dysfunction domain of the PSQI components was significantly associated with higher triglyceride levels (beta=0.066, p=0.004).

Conclusion: Poorer lipid profile was independently associated with poor sleep quality, assessed by the PSQI questionnaire, regardless of a normal sleep duration and accounting for OSA and socio-economic status.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Geovanini, Glaucylara Reis
Lorenzi-Filho, Geraldo
de Paula, Lilian K
Oliveira, Camila M
Alvim, Rafael O
Beijamini, Felipe
Negrão, André B
von Schantz, MalcolmM.Von.Schantz@surrey.ac.uk
Knutson, Kristen L
Krieger, José E
Pereira, Alexandre C
Date : 30 January 2019
DOI : 10.1016/j.sleep.2018.12.028
Copyright Disclaimer : © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Lipids; Sleep quality; PSQI; Pittsburgh sleep quality index; Very-low density lipoprotein cholesterol; Obstructive sleep apnea
Depositing User : Clive Harris
Date Deposited : 14 Jan 2019 15:12
Last Modified : 23 Oct 2019 10:39
URI: http://epubs.surrey.ac.uk/id/eprint/850135

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