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Complex interactions in soil-transmitted helminth co-infections from a cross-sectional study in Sri Lanka

Lepper, H.C., Prada, Joaquin, Davis, E.L., Gunawardena, S.A. and DÃirdre Hollingsworth, T. (2018) Complex interactions in soil-transmitted helminth co-infections from a cross-sectional study in Sri Lanka Transactions of the Royal Society of Tropical Medicine and Hygiene, 112 (8). pp. 397-404.

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Abstract

Background: Co-infection with multiple soil-transmitted helminth (STH) species is common in communities with a high STH prevalence. The life histories of STH species share important characteristics, particularly in the gut, and there is the potential for interaction, but evidence on whether interactions may be facilitating or antagonistic are limited. Methods: Data from a pretreatment cross-sectional survey of STH egg deposition in a tea plantation community in Sri Lanka were analysed to evaluate patterns of co-infection and changes in egg deposition. Results: There were positive associations between Trichuris trichiura (whipworm) and both Necator americanus (hookworm) and Ascaris lumbricoides (roundworm), but N. americanus and Ascaris were not associated. N. americanus and Ascaris infections had lower egg depositions when they were in single infections than when they were co-infecting. There was no clear evidence of a similar effect of co-infection in Trichuris egg deposition. Conclusions: Associations in prevalence and egg deposition in STH species may vary, possibly indicating that effects of co-infection are species dependent. We suggest that between-species interactions that differ by species could explain these results, but further research in different populations is needed to support this theory. © The Author(s) 2018. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
Lepper, H.C.
Prada, Joaquinj.prada@surrey.ac.uk
Davis, E.L.
Gunawardena, S.A.
DÃirdre Hollingsworth, T.
Date : 25 July 2018
DOI : 10.1093/trstmh/try068
Uncontrolled Keywords : Ascaris lumbricoides, Co-infection, Epidemiology, Necator americanus, Sri Lanka, Trichuris trichiura
Depositing User : Rebecca Cooper
Date Deposited : 03 Jan 2019 09:14
Last Modified : 26 Feb 2019 14:34
URI: http://epubs.surrey.ac.uk/id/eprint/850090

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