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Effects of ageing and sex on complexity in the human sleep EEG: a comparison of three symbolic dynamic analysis methods

Tosun, Pinar Deniz, Dijk, Derk-Jan, Winsky-Sommerer, Raphaelle-Valia and Abasolo, Daniel (2018) Effects of ageing and sex on complexity in the human sleep EEG: a comparison of three symbolic dynamic analysis methods Complexity.

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Abstract

Symbolic dynamic analysis (SDA) methods have been applied to biomedical signals and have been proven efficient in characterising differences in the electroencephalogram (EEG) in various conditions (e.g., epilepsy, Alzheimer’s and Parkinson’s diseases). In this study, we investigated the use of SDA on EEGs recorded during sleep. Lempel-Ziv Complexity (LZC), Permutation Entropy (PE), Permutation Lempel-Ziv Complexity (PLZC), as well as power spectral analysis based on the fast Fourier transform (FFT), were applied to 8-h sleep EEG recordings in healthy men (n=31) and women (n=29), aged 20-74 years. The results of the SDA methods and FFT analysis were compared and the effects of age and sex were investigated. Surrogate data were used to determine whether the findings with SDA methods truly reflected changes in non-linear dynamics of the EEG and not merely changes in the power spectrum. The surrogate data analysis showed that LZC merely reflected spectral changes in EEG activity, whereas PE and PLZC reflected genuine changes in the non-linear dynamics of the EEG. All three SDA techniques distinguished the vigilance states (i.e. wakefulness, REM sleep, NREM sleep and its sub stages: stage 1, stage 2 and slow wave sleep). Complexity of the sleep EEG increased with ageing. Sex on the other hand did not affect the complexity values assessed with any of these three SDA methods, even though FFT detected sex differences. This study shows that SDA provides additional insights into the dynamics of sleep EEG and how it is affected by ageing.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Mechanical Engineering Sciences
Authors :
NameEmailORCID
Tosun, Pinar Deniz
Dijk, Derk-JanD.J.Dijk@surrey.ac.uk
Winsky-Sommerer, Raphaelle-ValiaR.Winsky-Sommerer@surrey.ac.uk
Abasolo, DanielD.Abasolo@surrey.ac.uk
Date : 2018
Funders : Leverhulme Trust
Copyright Disclaimer : Copyright 2018 The Author(s). This is an Open Access article, distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Depositing User : Users 8 not found.
Date Deposited : 29 Nov 2018 12:45
Last Modified : 06 Jul 2019 05:26
URI: http://epubs.surrey.ac.uk/id/eprint/849954

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