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Altered mRNA expression levels of vaspin and adiponectin in peripheral blood mononuclear cells of systemic lupus erythematosus patients

Zhang, Tian-Ping, Zhao, Yu-Lan, Li, Xiao-Mei, Wu, Chang-Hao, Pan, Hai-Feng and Ye, Dong-Qing (2019) Altered mRNA expression levels of vaspin and adiponectin in peripheral blood mononuclear cells of systemic lupus erythematosus patients Clinical and Experimental Rheumatology, 37 (3). pp. 458-464.

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Abstract

<p>Objectives</p> <p>Increasing studies have indicated the association between adipokines and multiple autoimmune diseases. This study aimed to evaluate the mRNA expression levels of vaspin, adiponectin and adrenomedullin in peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE), as well as their clinical associations. </p> <p>Methods</p> <p>A total of 46 SLE patients and 51 normal controls were recruited. The three adipokines expression levels in PBMCs from SLE patients were measured by qRT-PCR, and their associations with major clinical and laboratory parameters of SLE patients were also analyzed. </p> <p>Results</p> <p>Compared with normal controls, vaspin expression level in PBMCs was significantly decreased (P < 0.001), whereas adiponectin expression level was significantly higher in SLE patients (P < 0.001). There was no significant difference in adrenomedullin expression level between SLE patients and normal controls. Vaspin and adrenomedullin expression levels in more active SLE were significantly lower than those in less active SLE (P = 0.012, P = 0.046, respectively). No significant difference in these adipokines expression levels was observed between SLE patients with and without lupus nephritis (LN). There was also no significant association between mRNA levels of these adipokines and major clinical and laboratory parameters.</p> <p>Conclusion</p> <p>Altered vaspin, adiponectin expression levels, and the associations between vaspin, adrenomedullin levels and disease activity in SLE patients suggested that these adipokines might play a role in SLE.</p>

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Zhang, Tian-Ping
Zhao, Yu-Lan
Li, Xiao-Mei
Wu, Chang-HaoC.Wu@surrey.ac.uk
Pan, Hai-Feng
Ye, Dong-Qing
Date : 10 May 2019
Copyright Disclaimer : © 2018 Clinical and Experimental Rheumatology
Uncontrolled Keywords : Adipokine; Vaspin; Adiponectin; Adrenomedullin; Systemic lupus erythematosus
Related URLs :
Additional Information : Funding: this work was supported by grants from the National Natural Science Foundation of China (81573222, 81473058); CW gratefully acknowledges support from the Royal Society-Newton Mobility (IE151259).
Depositing User : Melanie Hughes
Date Deposited : 28 Nov 2018 10:33
Last Modified : 30 Oct 2019 12:26
URI: http://epubs.surrey.ac.uk/id/eprint/849946

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