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Robust reconstruction of local optic axis orientation with fiber-based polarization-sensitive optical coherence tomography

Li, Qingyun, Karnowski, Karol, Noble, Peter B., Cairncross, Alvenia, James, Alan, Villiger, Martin and Sampson, David D. (2018) Robust reconstruction of local optic axis orientation with fiber-based polarization-sensitive optical coherence tomography Biomedical Optics Express, 9 (11). pp. 5437-5455.

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Abstract

It is challenging to recover local optic axis orientation from samples probed with fiber-based polarization-sensitive optical coherence tomography (PS-OCT). In addition to the effect of preceding tissue layers, the transmission through fiber and system elements, and imperfect system alignment, need to be compensated. Here, we present a method to retrieve the required correction factors from measurements with depth-multiplexed PS-OCT, which accurately measures the full Jones matrix. The correction considers both retardation and diattenuation and is applied in the wavenumber domain, preserving the axial resolution of the system. The robustness of the method is validated by measuring a birefringence phantom with a misaligned system. Imaging ex-vivo lamb trachea and human bronchus demonstrates the utility of reconstructing the local optic axis orientation to assess smooth muscle, which is expected to be useful in the assessment of airway smooth muscle thickness in asthma, amongst other fiber-based applications.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Li, Qingyun
Karnowski, Karol
Noble, Peter B.
Cairncross, Alvenia
James, Alan
Villiger, Martin
Sampson, David D.d.sampson@surrey.ac.uk
Date : 15 October 2018
DOI : 10.1364/BOE.9.005437
Copyright Disclaimer : © 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
Depositing User : Clive Harris
Date Deposited : 12 Nov 2018 16:12
Last Modified : 04 Apr 2019 15:54
URI: http://epubs.surrey.ac.uk/id/eprint/849854

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