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An experimental study of die filling of pharmaceutical powders using a rotary die filling system

Zakhvatayeva, A., Zhong, W., Makroo, H.A., Hare, C. and Wu, C. (2018) An experimental study of die filling of pharmaceutical powders using a rotary die filling system International Journal of Pharmaceutics, 553 (1-2). pp. 84-96.

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Abstract

Die filling is a critical process step in pharmaceutical tablet manufacturing. Mass and content uniformity of the tablets as well as production throughput depend upon the die filling performance of the formulations. The efficiency of the die filling process is influenced by powder properties, such as flowability, cohesion, particle size and morphology, as well as the process conditions. It is hence important to understand the influence of powder properties on the die filling performance. The purpose of the present study is to identify the critical material attributes that determine the efficiency of die filling. For this purpose, a model rotary die filling system was developed to mimic the die filling process in a typical rotary tablet press. The system consists of a round die table of 500 mm diameter, equipped with a rectangular die. The die table can rotate at an equivalent translational velocity of up to 1.5 m/s. The filling occurs when the die passes through a stationary shoe positioned above the die table. Using this system, die filling behaviours of 7 commonly used pharmaceutical excipients with various material characteristics (e.g. particle size distribution, sphericity and morphology) and flow properties were examined. The efficiency of die filling is evaluated using the concept of critical filling velocity. It was found that the critical filling velocity is strongly dependent on such properties as cohesion, flowability, average particle size and air sensitivity index. In particular, the critical filling velocity increases proportionally as the mean particle size, flow function, air permeability and air sensitivity index increase, while it decreases with the increase of specific energy and cohesion.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
NameEmailORCID
Zakhvatayeva, A.a.zakhvatayeva@surrey.ac.uk
Zhong, W.
Makroo, H.A.h.makroo@surrey.ac.uk
Hare, C.c.hare@surrey.ac.uk
Wu, C.c.y.wu@surrey.ac.uk
Date : 12 October 2018
DOI : 10.1016/j.ijpharm.2018.09.067
Copyright Disclaimer : © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Die filling; Tabletting; Flowability; Air sensitivity; Rotary press; Critical filling velocity
Depositing User : Clive Harris
Date Deposited : 24 Oct 2018 14:45
Last Modified : 14 Jun 2019 10:01
URI: http://epubs.surrey.ac.uk/id/eprint/849768

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