University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Biological effects of static magnetic field exposure in the context of MR-guided radiotherapy

Mohajer, Jonathan Kim, Nisbet, Andrew, Velliou, Eirini, Ajaz, Mazhar and Schettino, Giuseppe (2018) Biological effects of static magnetic field exposure in the context of MR-guided radiotherapy British Journal of Radiation, 92 (1094).

[img] Text
__homes.surrey.ac.uk_home_.System_Desktop_BJR-2.pdf - Accepted version Manuscript
Restricted to Repository staff only until 31 October 2019.

Download (419kB)
[img] Text
__homes.surrey.ac.uk_home_.System_Desktop_BJR-D-18-00484_R1.pdf - Accepted version Manuscript
Restricted to Repository staff only

Download (1MB)

Abstract

The clinical introduction of magnetic resonance imaging guided radiotherapy has prompted consideration of the potential impact of the static magnetic field on biological responses to radiation. This review provides an introduction to the mechanisms of biological interaction of radiation and magnetic fields individually, in addition to a description of the magnetic field effects on megavoltage photon beams at the macroscale, microscale and nanoscale arising from the Lorentz force on secondary charged particles.

A relatively small number of scientific studies have measured the impact of combined static magnetic fields and ionising radiation on biological endpoints of relevance to radiotherapy. Approximately half of these investigations found that static magnetic fields in combination with ionising radiation produced a significantly different outcome compared with ionising radiation alone. MRI strength static magnetic fields appear to modestly influence the radiation response via a mechanism distinct from modification to the dose distribution. This review intends to serve as a reference for future biological studies, such that understanding of static magnetic field plus ionising radiation synergism may be improved, and if necessary, accounted for in magnetic resonance imaging guided radiotherapy treatment planning.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
NameEmailORCID
Mohajer, Jonathan Kim
Nisbet, AndrewA.Nisbet@surrey.ac.uk
Velliou, Eirinie.velliou@surrey.ac.uk
Ajaz, Mazharm.ajaz@surrey.ac.uk
Schettino, Giuseppegiuseppe.schettino@surrey.ac.uk
Date : 31 October 2018
DOI : 10.1259/bjr.20180484
Copyright Disclaimer : © 2019 The Authors. Published by the British Institute of Radiology
Depositing User : Melanie Hughes
Date Deposited : 19 Oct 2018 07:45
Last Modified : 19 Mar 2019 11:02
URI: http://epubs.surrey.ac.uk/id/eprint/849735

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800