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Evaluation of the separation and purification of 227 Th from its decay progeny by anion exchange and extraction chromatography

Ivanov, P.I., Collins, S.M., Van Es, E., García-Miranda, M., Jerome, S.M. and Russell, B.C. (2017) Evaluation of the separation and purification of 227 Th from its decay progeny by anion exchange and extraction chromatography Applied Radiation and Isotopes, 124. pp. 100-105.

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Abstract

Thorium-227 is currently undergoing evaluation as a potential radionuclide for targeted cancer therapy, and as such a high chemical purity of the material is required. To establish a reliable procedure for radiochemical isolation of 227Th from the parent 227Ac and decay progeny, which includes the radiotherapeutic 223Ra, the performance of three different separation schemes based on ion-exchange and extraction chromatography have been evaluated. The results suggest that both ion exchange and extraction chromatographic techniques can be successfully used for the separation of 227Th from its decay progeny, however extraction chromatographic resins demonstrate favourable performance in terms of Th recovery and purification from radionuclide impurities.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
NameEmailORCID
Ivanov, P.I.
Collins, S.M.
Van Es, E.e.vanes@surrey.ac.uk
García-Miranda, M.
Jerome, S.M.
Russell, B.C.
Date : January 2017
DOI : 10.1016/j.apradiso.2017.03.020
Copyright Disclaimer : © 2017 Elsevier Ltd. All rights reserved.
Uncontrolled Keywords : 227Th; Radiopharmaceuticals; Radiochemical separation; Ion-exchange; Extraction chromatography
Depositing User : Claudio Svaluto
Date Deposited : 08 Oct 2018 14:11
Last Modified : 08 Oct 2018 14:11
URI: http://epubs.surrey.ac.uk/id/eprint/849607

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